Evidence map›Paper›PMID 34635780›Full record

ArticleExperimental & molecular medicine2021

Leukotriene B4 receptor-2 contributes to KRAS-driven lung tumor formation by promoting interleukin-6-mediated inflammation.

Jae-Hyun Jang, Donghwan Park, Guen-Soo Park, Dong-Wook Kwak, JaeIn Park, Dae-Yeul Yu, Hye Jin You, Jae-Hong Kim

Open access · goldAbstract read
In one paragraph

Article in Experimental & molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Two distinct forms of human BLT2: long-form and short-form BLT2.Frontiers in cell and developmental biology · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jae-Hyun Jang *Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Donghwan Park *Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Guen-Soo Park *Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Dong-Wook KwakDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
JaeIn ParkDepartment of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Republic of Korea.
Dae-Yeul YuDisease Model Research Laboratory, Genome Editing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, 34141, Republic of Korea.
Hye Jin YouDivision of Translational Science, National Cancer Center, Goyang, 10408, Republic of Korea.ORCID http://orcid.org/0000-0001-5566-5171
Jae-Hong KimDivision of Life Sciences, College of Life Sciences, Korea University, Seoul, 02841, Republic of Korea. jhongkim@korea.ac.kr.ORCID http://orcid.org/0000-0002-8019-0208
Korea University · KRKorea Research Institute of Bioscience and Biotechnology · KRNational Cancer Center · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although lung cancer is the leading cause of cancer-related deaths worldwide and KRAS is the most frequently mutated oncogene in lung cancer cases, the mechanism by which KRAS mutation drives lung cancer has not been fully elucidated. Here, we report that the expression levels of leukotriene B

Indexed as

Interleukin-6Lung NeoplasmsAnimalsHumansInflammationLeukotriene B4MiceProto-Oncogene Proteins p21(ras)Receptors, Leukotriene B4Hras protein, mouseInterleukin-6KRAS protein, humanLeukotriene B4LTB4R2 protein, humanLtb4r2 protein, mouseProto-Oncogene Proteins p21(ras)Receptors, Leukotriene B4

Identifiers

PMID34635780
PMCPMC8569214
OpenAlexW3206852645

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.