ArticleScientific reports2021
Assessment of the relationship between serum uric acid levels and liver enzymes activity in Bangladeshi adults.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
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Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Hyperuricemia Is Associated With the Risk of Atrial Fibrillation Independent of Sex: A Dose-Response Meta-Analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- Evaluation of 12-Week Standardized Beetroot Extract Supplementation in Older Participants: A Preliminary Study of Human Health Safety.Nutrients · 2024Trial
- Interactions between serum uric acid and gut microbiota: implications for metabolic health.Metabolism open · 2026Review
- Association between different metabolic obesity phenotypes and hyperuricemia: the modifying role of liver enzymes.Frontiers in public health · 2026Article
- Deciphering the Association of Fasting Blood Glucose With Gamma-Glutamyl Transferase and Uric Acid:Sultan Qaboos University medical journal · 2026Article
- The Impact of Hyperuricemia on Pharmacokinetics in Sprague-Dawley Rats.European journal of drug metabolism and pharmacokinetics · 2025Article
- Investigating the Relationship Between Serum Uric Acid and Dyslipidemia in Young Adults in Bangladesh.Endocrinology, diabetes & metabolism · 2025Article
- Investigating the prevalence and associated factors of elevated liver enzymes and dyslipidemia during pregnancy.Scientific reports · 2025Article
- Association between Body Mass Index and Serum Uric Acid: mediation analysis involving liver enzymes indicators.BMC public health · 2024Article
- Inverted U-shaped associations between serum uric acid and fasting - plasma glucose level in non-diabetic, pre-diabetic, and diabetic adults: A population-based study in China.Journal of diabetes investigation · 2024Article
- What Do Higher Alanine Aminotransferase Levels Mean in Premature Ovarian Insufficiency?Reproductive sciences (Thousand Oaks, Calif.) · 2024Article
- Hyperuricemia and associated factors: The case of outpatients at the Bafoussam Regional Hospital- Cameroon, an analytical cross-sectional study.Health science reports · 2024Article
- The Prevalence of Hyperuricemia and the Association Between Hyperuricemia and Age in Patients with Psychiatric Disorders to a General Hospital: A Cross-Section Study.International journal of general medicine · 2024Article
- A Gender-, Age-, and Weight Status-Specific Analysis of the High Prevalence of Hyperuricemia Among Chinese Children and Adolescents with Obesity.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Prevalence and factors associated with metabolic syndrome in university students and academic staff in Bangladesh.Scientific reports · 2023Article
- Prevalence of hyperuricaemia among adults from Ningxia Hui Autonomous Region, China: a cross-sectional study.BMJ open · 2023Article
- Associations of Serum Uric Acid Level With Liver Enzymes, Nonalcoholic Fatty Liver Disease, and Liver Fibrosis in Korean Men and Women: A Cross-Sectional Study Using Nationally Representative Data.Journal of Korean medical science · 2023Article
- Prevalence of dyslipidemia and its associated factors among university academic staff and students in Bangladesh.BMC cardiovascular disorders · 2023Article
- The prevalence and factors associated with obesity and hypertension in university academic staff: a cross-sectional study in Bangladesh.Scientific reports · 2023Article
- Trends in serum uric acid levels among Korean children and adolescents between 2016 and 2020: a nationwide study.European journal of pediatrics · 2023Article
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Authors and funding
9 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Serum uric acid (SUA) level has been suggested to be associated with cardiovascular disease, diabetes and metabolic syndrome. However, little is known about the relationship between SUA and liver enzymes activity in the general population. The present study aimed to assess the relationship between SUA and serum liver enzymes in an adult population in Bangladesh. In this cross-sectional study, a total of 410 blood samples were collected from apparently healthy adults aged > 18 years. SUA, liver enzymes, lipid profile and other biochemical markers were measured in the collected samples by using standard methods. Multinomial logistic regression model was used to assess the relationship between SUA and elevated levels of liver enzymes among the participants. Overall, the prevalence of hyperuricemia was 30.1% with 32.2% in male and 18.6% in female participants. About 33% of the participants had at least one or more elevated levels of liver enzymes. The mean level of SUA was significantly higher in males (389.3 ± 96.9 µmol/L) than in the female (290.4 ± 89.8 µmol/L) subjects (p < 0.001). There was a significant difference in the mean levels of serum ALT and GGT between the male (34.5 ± 16.0 U/L and 26.7 ± 19.5 U/L, respectively) and female (25.0 ± 13.0 U/L and 19.5 ± 13.2 U/L, respectively) participants (p < 0.001 and p < 0.01, respectively). An increasing trend was observed in the mean levels of serum ALT and GGT across the SUA quartile groups (p < 0.001 and p < 0.01, respectively). SUA showed a positive and significant correlation with serum ALT (p < 0.001) and GGT (p < 0.01). In further statistical analysis after adjustment for potential confounders, SUA showed an independent and significant association with serum ALT and GGT in all regression models. In conclusion, SUA was strongly associated with serum levels of ALT and GGT after adjustment for potential confounders. More prospective studies are needed to clarify the complex relationship between SUA and liver enzymes in the general population.
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