Evidence map›Paper›PMID 34635711›Full record

ArticleScientific reports2021

Anthrahydroquinone-2-6-disulfonate is a novel, powerful antidote for paraquat poisoning.

Jin Qian, Chun-Yuan Wu, Dong-Ming Wu, Li-Hua Li, Qi Li, Tang Deng, Qi-Feng Huang, Shuang-Qin Xu, Hang-Fei Wang, Xin-Xin Wu and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Jin Qian *Key Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Chun-Yuan Wu *Institute of Environment and Plant Protection, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
Dong-Ming WuInstitute of Environment and Plant Protection, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, China.
Li-Hua LiKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Qi LiKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Tang DengKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Qi-Feng HuangKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Shuang-Qin XuKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Hang-Fei WangKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Xin-Xin WuKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China.
Zi-Yi ChengKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China. chengziyi@hainmc.edu.cn.
Chuan-Zhu LvEmergency Medicine Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. lvchuanzhu677@126.com.
Xiao-Ran LiuKey Laboratory of Emergency and Trauma of Ministry of Education, The First Affiliated Hospital of Hainan Medical University, Hainan Medical University, Haikou, 571199, China. hy0203049@hainmc.edu.cn.
Hainan Medical University · CNChinese Academy of Tropical Agricultural Sciences · CNUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Paraquat (PQ) is a widely used fast-acting pyridine herbicide. Accidental ingestion or self-administration via various routes can cause severe organ damage. Currently, no effective antidote is available commercially, and the mortality rate of poisoned patients is exceptionally high. Here, the efficacy of anthrahydroquinone-2-6-disulfonate (AH

Indexed as

Oxidative StressA549 CellsAnimalsAnthraquinonesAntidotesAntioxidantsCell SurvivalHerbicidesHumansMaleMitochondriaParaquatPoisoningRatsRats, Sprague-Dawleyanthrahydroquinone-2,6-disulfonateAnthraquinonesAntidotesAntioxidantsHerbicidesParaquat

Identifiers

PMID34635711
PMCPMC8505516
OpenAlexW3207556601

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.