Evidence map›Paper›PMID 34635654›Full record

ArticleNature communications2021

Spontaneous assembly of redox-active iron-sulfur clusters at low concentrations of cysteine.

Sean F Jordan, Ioannis Ioannou, Hanadi Rammu, Aaron Halpern, Lara K Bogart, Minkoo Ahn, Rafaela Vasiliadou, John Christodoulou, Amandine Maréchal, Nick Lane

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 65 citations in OpenAlex.

  1. Review
  2. Review
  3. The Ascent of Miniproteins.Biochemistry · 2026
    Review
  4. Article
  5. Multivalent recognition of ferritin by full-length NCOA4 enables robust ferritinophagy.Protein science : a publication of the Protein Society · 2026
    Article
  6. Regulation of mitochondrial iron homeostasis in tumor cells.Molecular medicine (Cambridge, Mass.) · 2026
    Review
  7. Article
  8. Article
  9. An Archean atmosphere rich in sulfur biomolecules.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Iron sulfide-catalyzed gaseous CONature communications · 2024
    Article
  16. Iron: Life's primeval transition metal.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  17. Article
  18. The prebiotic emergence of biological evolution.Royal Society open science · 2024
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Sean F JordanCentre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.ORCID 0000-0001-8403-1100
Ioannis Ioannou *Centre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Hanadi Rammu *Centre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.ORCID 0000-0002-9597-5059
Aaron HalpernCentre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
Lara K BogartUCL Healthcare Biomagnetics Laboratory, University College London, 21 Albemarle Street, London, W1S 4BS, UK.
Minkoo AhnInstitute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.
Rafaela VasiliadouCentre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK.
John ChristodoulouInstitute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.ORCID 0000-0002-6710-3843
Amandine MaréchalInstitute of Structural and Molecular Biology, University College London, London, WC1E 6BT, UK.ORCID 0000-0003-3460-3806
Nick LaneCentre for Life's Origin and Evolution, Department of Genetics, Evolution and Environment, University College London, Darwin Building, Gower Street, London, WC1E 6BT, UK. nick.lane@ucl.ac.uk.ORCID 0000-0002-5433-3973
Centre for Life · GBInstitute of Structural and Molecular Biology · GBUniversity College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/V003542/1Medical Research Council MR/M00936X/1Medical Research Council MR/T032154/1Wellcome Trust 206409/Z/17/Z
6 · The paper itself

Abstract

Iron-sulfur (FeS) proteins are ancient and fundamental to life, being involved in electron transfer and CO

Indexed as

Models, ChemicalOrigin of LifeBicarbonatesCarbon DioxideCysteineElectrochemical TechniquesElectron TransportHydrogen-Ion ConcentrationIronOxidation-ReductionSpectroscopy, MossbauerSulfidesSulfurBicarbonatesCarbon DioxideCysteinegreigiteIronSulfidesSulfur

Identifiers

PMID34635654
PMCPMC8505563
OpenAlexW3205584884

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.