ArticleAnnals of laboratory medicine2022
Diagnostic Characteristics of Urinary Red Blood Cell Distribution Incorporated in UF-5000 for Differentiation of Glomerular and Non-Glomerular Hematuria.
Article in Annals of laboratory medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 15 citations in OpenAlex.
- Chronic kidney disease progression in glomerular diseases: is hematuria a key risk factor?Pediatric nephrology (Berlin, Germany) · 2026Review
- Deep Learning-Assisted Classification of Urinary Red Blood Cell Morphology for Glomerular Hematuria Screening: A Pilot Study.Journal of clinical laboratory analysis · 2026Article
- Red blood cell subpopulation ratios identify samples at risk of dipstick-flow cytometry hematuria discordance in Sysmex UN-Series analyzers.Practical laboratory medicine · 2026Article
- Enhancing Glomerular Hematuria Identification in Automated Urinalysis Using a Light Gradient Boosting Machine-Based Model: A Diagnostic Accuracy Study.Annals of laboratory medicine · 2026Article
- Urinary Red Blood Cell Distribution for Detection of Glomerular Hematuria: A Biopsy-Based Comparison with Direct Microscopy.Diagnostics (Basel, Switzerland) · 2026Article
- Time-Updated Hematuria and Kidney Disease Progression in IgAN.Kidney international reports · 2026Article
- Machine Learning-Based Analysis of UF-5000 Scattergrams Improves the Identification of Urinary Dysmorphic Red Blood Cells.Annals of laboratory medicine · 2026Article
- Multicenter study of the diagnostic value of erythrocyte morphology assessment by the EH-2090 for differentiation of glomerular and non-glomerular hematuria.BMC nephrology · 2026Article
- Development of a Novel UPC (Urine Red Blood Cell Distribution, Proteinuria, and Serum Creatinine) Index to Differentiate Glomerular from Nonglomerular Hematuria.Journal of clinical laboratory analysis · 2026Article
- The urine examination: a modern technological test with a very ancient history.Advances in laboratory medicine · 2026Review
- The Diagnostic Value of Cellular Phenotyping and Pathological Casts Using Urine Flow Cytometry in Children with Lupus Nephritis.Diseases (Basel, Switzerland) · 2026Article
- Comparative evaluation of three automated urine sediment analyzers excluding cutoff-related trade-offs.iScience · 2026Article
- Comparison of Urinary Red Blood Cell Distribution (URD) and Dysmorphic Red Blood Cells for Detecting Glomerular Hematuria: A Multicenter Study.Journal of clinical laboratory analysis · 2025Article
- UF-5000 urinary erythrocyte parameters versus urinary aberrant erythrocytes and acanthocytes for diagnosing IgA glomerular hematuria.Scientific reports · 2025Article
- MyACR: A Point-of-Care Medical Device for Determination of Albumin-Creatinine Ratio (uACR) in Random Urine Samples as a Marker of Nephropathy.Diagnostics (Basel, Switzerland) · 2024Article
- Performance analysis of urine formed element analyzer EH-2090 was found to have good accuracy in detecting RBCs and WBCs when compared to manual microscopic.Translational andrology and urology · 2024Article
- Evaluation of the fully automated urine particle analyzer UF-1500.Journal of clinical laboratory analysis · 2023Article
- Microscopic hematuria as a risk factor for IgAN progression: considering this biomarker in selecting and monitoring patients.Clinical kidney journal · 2023Review
- How to define and assess the clinically significant causes of hematuria in childhood.Pediatric nephrology (Berlin, Germany) · 2023Article
- The application of new complex indicators in the detection of urine.BMC nephrology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAutomated urine sediment analysis has been developed to address the limitations of microscopic examination of dysmorphic red blood cells (RBCs). We evaluated the urinary RBC distribution (URD) parameter of a recently launched automated urinary flow cytometry analyzer, UF-5000 (Sysmex, Kobe, Japan), to differentiate glomerular hematuria (GH) from non-GH (NGH).
methodsSamples submitted for urine sediment analysis from patients with hematuria (>20 RBCs/μL) were divided into derivation (N=156; 101 GH, 55 NGH) and validation cohorts (N=107; 60 GH, 47 NGH). The clinical diagnosis of GH or NGH was established based on clinical data review. Differences in UF-5000 parameters (URD, small RBC, lysed RBC, RBC-P70FSC, RBC-SF-FSC-W, mean forward-scattered light, and mean side-scattered light) between GH and NGH, and areas under the ROC curves (AUC) were analyzed in the derivation cohort. The derived ideal cut-off value was evaluated in the validation cohort. We applied the Kitasato criteria to compare the diagnostic performance.
resultsURD (%), differed significantly between GH and NGH (
conclusionsURD is a rapid, objective, and quantitative measure that can be used to differentiate GH and NGH.
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Registered trials
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