Evidence map›Paper›PMID 34635507›Full record

ArticleMolecular cancer research : MCR2022

Regulation of Chemosensitivity in Human Medulloblastoma Cells by p53 and the PI3 Kinase Signaling Pathway.

Aisha Naeem, Varsha Harish, Sophie Coste, Erika M Parasido, Muhammad Umer Choudhry, Lawrence F Kromer, Chukuemeka Ihemelandu, Emanuel F Petricoin, Mariaelena Pierobon, Muhammad Saad Noon and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
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  8. MDM2- an indispensable player in tumorigenesis.Molecular biology reports · 2023
    Review
  9. Article
  10. Cell Senescence and Central Regulators of Immune Response.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Aisha NaeemDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-3542-3383
Varsha HarishDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Sophie CosteDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.ORCID 0000-0002-4505-7954
Erika M ParasidoDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Muhammad Umer ChoudhryDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Lawrence F KromerDepartment of Neuroscience, Georgetown University Medical Center, Washington, DC.
Chukuemeka IhemelanduDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Emanuel F PetricoinGeorge Mason University, Center for Applied Proteomics and Molecular Medicine, Manassas, Virginia.
Mariaelena PierobonGeorge Mason University, Center for Applied Proteomics and Molecular Medicine, Manassas, Virginia.
Muhammad Saad NoonData Science Institute, University of Arizona, Texas, Arizona.ORCID 0000-0001-5785-5788
Venkata Mahidhar YenugondaDepartment of Drug Discovery and Nanomedicine, Saint John's Cancer Institute, Santa Monica, California.
Maria AvantaggiatiDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Gary M KupferDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.
Stanley FrickeDepartment of Radiology, Georgetown University Medical Center, Washington, DC.
Olga RodriguezDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC.ORCID 0000-0003-2017-1096
Chris AlbaneseDepartment of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC. albanese@georgetown.edu.
Georgetown University · USGeorge Mason University · USSaint John's Health Center · USUniversity of Arizona · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Institutional Career Development CoreKL2TR001432 · NCATS · GEORGETOWN UNIVERSITY · PI UMANS, JASON G · 2015 to 2024
$7.5M
NCATS NIH HHS KL2 TR001432NCI NIH HHS P30 CA051008
6 · The paper itself

Abstract

In medulloblastoma, p53 expression has been associated with chemoresistance and radiation resistance and with poor long-term outcomes in the

Indexed as

Cerebellar NeoplasmsHumansMedulloblastomaPhosphatidylinositol 3-KinaseSignal TransductionTumor Suppressor Protein p53Phosphatidylinositol 3-KinaseTumor Suppressor Protein p53

Identifiers

PMID34635507
PMCPMC8738155
OpenAlexW3207266271

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.