Evidence map›Paper›PMID 34635163›Full record

ReviewAlzheimer's research & therapy2021

Brain Health Services: organization, structure, and challenges for implementation. A user manual for Brain Health Services-part 1 of 6.

Daniele Altomare, José Luis Molinuevo, Craig Ritchie, Federica Ribaldi, Emmanuel Carrera, Bruno Dubois, Frank Jessen, Laura McWhirter, Philip Scheltens, Wiesje M van der Flier and 4 more

2 registry-linked trialsOpen access · goldAbstract readReview
In one paragraph

Review in Alzheimer's research & therapy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07284316 phase2 / phase3active not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of a Multidomain Intervention Plus Turmeric on the Prevention of Cognitive Decline in People Over 55 Years of Age With Insulin Resistance: A Randomized Clinical Trial

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2025 to 2027Enrolled100ConditionsCognitive Decline, Subjective Cognitive Impairment, Insulin ResistanceArmsTurmeric extract, Control: Placebo. 500mg gelatin in capsules 2 times a day
NCT07668440 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Preliminary Assessment of the Effects, Usability, Satisfaction, Barriers, and Benefits of a Remote, Multidomain Intervention Supported by a Website to Prevent Cognitive Decline in Older Adults

TypeinterventionalSponsorInstituto Mexicano del Seguro SocialRan2026 to 2027Enrolled71ConditionsCoginitive DysfunctionArmsMulti-domain intervention: Physical activity, cognitive training, and educational program through a website
3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Observational
  8. Review
  9. Brain health clinics - An evolving clinical pathway?The journal of prevention of Alzheimer's disease · 2025
    Observational
  10. Article
  11. Article
  12. Subjective cognitive decline: Memory complaints, cognitive awareness, and metacognition.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024
    Review
  13. Article
  14. The expectations and experiences of patients regarding the diagnostic workup at a specialized memory clinic: An interview study.Health expectations : an international journal of public participation in health care and health policy · 2024
    Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 7 countries.

Daniele Altomare *Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland. Daniele.Altomare@unige.ch.ORCID http://orcid.org/0000-0003-1905-8993
José Luis Molinuevo *Barcelonaβeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.
Craig RitchieCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Federica RibaldiLaboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.
Emmanuel CarreraDepartment of Neurology, Stroke Center, University Hospitals and University of Geneva, Geneva, Switzerland.
Bruno DuboisInstitut de la Mémoire et de la Maladie d'Alzheimer, IM2A, INSERM, Institut du Cerveau et de la Moelle Épinière, UMR-S975, Groupe Hospitalier Pitié-Salpêtrière, AP-HP, Sorbonne Université, Paris, France.
Frank JessenDepartment of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany.
Laura McWhirterCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.
Philip ScheltensDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Wiesje M van der FlierDepartment of Neurology, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Bruno VellasGérontopole of Toulouse, University Hospital of Toulouse (CHU-Toulouse), Toulouse, France.
Jean-François Démonet *Centre Leenaards de la Mémoire, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
Giovanni B Frisoni *Laboratory of Neuroimaging of Aging (LANVIE), University of Geneva, Geneva, Switzerland.
European Task Force for Brain Health Services
University of Geneva · CHUniversity of Edinburgh · GBAmsterdam Neuroscience · NLUniversity Hospital of Lausanne · CHInserm · FRPasqual Maragall Foundation · ESUniversity of Cologne · DEAmsterdam University Medical Centers · NLUniversity Hospital of Geneva · CHUniversity of Brescia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dementia has a devastating impact on the quality of life of patients and families and comes with a huge cost to society. Dementia prevention is considered a public health priority by the World Health Organization. Delaying the onset of dementia by treating associated risk factors will bring huge individual and societal benefit. Empirical evidence suggests that, in higher-income countries, dementia incidence is decreasing as a result of healthier lifestyles. This observation supports the notion that preventing dementia is possible and that a certain degree of prevention is already in action. Further reduction of dementia incidence through deliberate prevention plans is needed to counteract its growing prevalence due to increasing life expectancy.An increasing number of individuals with normal cognitive performance seek help in the current memory clinics asking an evaluation of their dementia risk, preventive interventions, or interventions to ameliorate their cognitive performance. Consistent evidence suggests that some of these individuals are indeed at increased risk of dementia. This new health demand asks for a shift of target population, from patients with cognitive impairment to worried but cognitively unimpaired individuals. However, current memory clinics do not have the programs and protocols in place to deal with this new population.We envision the development of new services, henceforth called Brain Health Services, devoted to respond to demands from cognitively unimpaired individuals concerned about their risk of dementia. The missions of Brain Health Services will be (i) dementia risk profiling, (ii) dementia risk communication, (iii) dementia risk reduction, and (iv) cognitive enhancement. In this paper, we present the organizational and structural challenges associated with the set-up of Brain Health Services.

Indexed as

Cognitive DysfunctionQuality of LifeBrainCognitionHealth ServicesHumansAgingAlzheimer’s diseaseBrain Health ServicesCognitive enhancementDementiaDementia riskPersonalized medicinePreventionRisk communicationRisk reduction

Identifiers

PMID34635163
PMCPMC8507194
OpenAlexW3205732310

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.