Evidence map›Paper›PMID 34635022›Full record

ReviewBioengineered2021

Emerging Advances of Non-coding RNAs and Competitive Endogenous RNA Regulatory Networks in Asthma.

Xiaoxu Wang, Hui Chen, Jingjing Liu, Linlin Gai, Xinyi Yan, Zhiliang Guo, Fengxia Liu

Open access · goldAbstract readReview
In one paragraph

Review in Bioengineered, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Connecting the Dots: How MicroRNAs Link Asthma and Atherosclerosis.International journal of molecular sciences · 2025
    Review
  4. Copy Number Variation in Asthma: An Integrative Review.Clinical reviews in allergy & immunology · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Non-coding RNAs regulating mitochondrial function in cardiovascular diseases.Journal of molecular medicine (Berlin, Germany) · 2023
    Review
  9. Article
  10. Article
  11. Review
  12. Epigenetic regulation of immune function in asthma.The Journal of allergy and clinical immunology · 2022
    Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Xiaoxu WangClinical Medicine College, Weifang Medical University, Weifang China.
Hui ChenClinical Medicine College, Weifang Medical University, Weifang China.
Jingjing LiuClinical Medicine College, Weifang Medical University, Weifang China.
Linlin GaiDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People's Hospital, Weifang China.
Xinyi YanDepartment of Central Laboratory, The First Affiliated Hospital of Weifang Medical University/Weifang People's Hospital, Weifang China.
Zhiliang GuoDepartment of Spine Surgery, The 80th Group Army Hospital of Chinese PLA, Weifang China.
Fengxia LiuDepartment of Allergy, The First Affiliated Hospital of Weifang Medical University/ Weifang People's Hospital, Weifang China.
Weifang People's Hospital · CNWeifang Medical University · CN307th Hospital of Chinese People’s Liberation Army · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Asthma is a chronic inflammatory disease characterized by airway remodeling and bronchial hyperresponsiveness. A variety of effector cells and cytokines jointly stimulate the occurrence of inflammatory response in asthma. Although the pathogenesis of asthma is not entirely clear, the possible roles of non-coding RNAs (ncRNAs) have been recently demonstrated. NcRNAs are non-protein-coding RNA molecules, such as circular RNAs (circRNAs), long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), which are involved in the regulation of a variety of biological processes. Mounting studies have shown that ncRNAs play pivotal roles in the occurrence and progression of asthma via competing endogenous RNA (ceRNA) regulatory networks. However, the specific mechanism and clinical application of ncRNAs and ceRNA regulatory networks in asthma have not been fully elucidated, which are worthy of further investigation. This paper comprehensively summarized the current progress on the roles of miRNAs, lncRNAs, circRNAs, and ceRNA regulatory networks in asthma, which can provide a better understanding for the disease pathogenesis and is helpful for identifying novel biomarkers for asthma.

Indexed as

AsthmaRNA, UntranslatedAnimalsBiomarkersCells, CulturedHumansMiceBiomarkersRNA, UntranslatedAsthmabiomarkercompeting endogenousnon-codingpathogenesis

Identifiers

PMID34635022
PMCPMC8806435
OpenAlexW3207314929

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.