ArticleNucleic acids research2022
VThunter: a database for single-cell screening of virus target cells in the animal kingdom.
Article in Nucleic acids research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- scGeneBank: cross-species screening of functional gene sets at single-cell resolution.Nucleic acids research · 2026Article
- scMOVIR: a single-cell multi-omics database for human viral infections and immune responses.Nucleic acids research · 2026Article
- A data-mining analysis of host solute carrier family proteins in SARS-CoV-2 infection with reference to brain endothelial cells and the blood-brain barrier in COVID-19.Frontiers in neurology · 2025Article
- GateView: A Multi-Omics Platform for Gene Feature Analysis of Virus Receptors within Human Normal Tissues and Tumors.Biomolecules · 2024Article
- Cellular receptors for mammalian viruses.PLoS pathogens · 2024Article
- SCAR: Single-cell and Spatially-resolved Cancer Resources.Nucleic acids research · 2024Article
- SCAN: Spatiotemporal Cloud Atlas for Neural cells.Nucleic acids research · 2024Article
- Uncovering the prominent role of satellite cells in paravertebral muscle development and aging by single-nucleus RNA sequencing.Genes & diseases · 2023Article
- Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin.Cell biology and toxicology · 2023Article
- SPEED: Single-cell Pan-species atlas in the light of Ecology and Evolution for Development and Diseases.Nucleic acids research · 2023Article
- Multi-omics analysis reveals genomic, clinical and immunological features of SARS-CoV-2 virus target genes in pan-cancer.Frontiers in immunology · 2023Article
- Screening of cell-virus, cell-cell, gene-gene crosstalk among animal kingdom at single cell resolution.Clinical and translational medicine · 2022Article
- The 2022 Nucleic Acids Research database issue and the online molecular biology database collection.Nucleic acids research · 2022Article
Corrections and comments
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Authors and funding
28 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viral infectious diseases are a devastating and continuing threat to human and animal health. Receptor binding is the key step for viral entry into host cells. Therefore, recognizing viral receptors is fundamental for understanding the potential tissue tropism or host range of these pathogens. The rapid advancement of single-cell RNA sequencing (scRNA-seq) technology has paved the way for studying the expression of viral receptors in different tissues of animal species at single-cell resolution, resulting in huge scRNA-seq datasets. However, effectively integrating or sharing these datasets among the research community is challenging, especially for laboratory scientists. In this study, we manually curated up-to-date datasets generated in animal scRNA-seq studies, analyzed them using a unified processing pipeline, and comprehensively annotated 107 viral receptors in 142 viruses and obtained accurate expression signatures in 2 100 962 cells from 47 animal species. Thus, the VThunter database provides a user-friendly interface for the research community to explore the expression signatures of viral receptors. VThunter offers an informative and convenient resource for scientists to better understand the interactions between viral receptors and animal viruses and to assess viral pathogenesis and transmission in species. Database URL: https://db.cngb.org/VThunter/.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.