Evidence map›Paper›PMID 34634786›Full record

ArticleObesity facts2021

Decreased Triglyceride and Increased Serum Lipoprotein Lipase Levels Are Correlated to Increased High-Density Lipoprotein-Cholesterol Levels after Laparoscopic Sleeve Gastrectomy.

Masahiro Ohira, Yasuhiro Watanabe, Takashi Yamaguchi, Hiroki Onda, Shuhei Yamaoka, Kazuki Abe, Shoko Nakamura, Sho Tanaka, Naoyuki Kawagoe, Taiki Nabekura and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity facts, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Masahiro OhiraDivision of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Yasuhiro WatanabeCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Takashi YamaguchiCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Hiroki OndaCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Shuhei YamaokaCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Kazuki AbeCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Shoko NakamuraCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Sho TanakaCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Naoyuki KawagoeDivision of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Toho University Ohashi Medical Center, Tokyo, Japan.
Taiki NabekuraDepartment of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
Takashi OshiroDepartment of Surgery, Toho University Sakura Medical Center, Chiba, Japan.
Daiji NagayamaCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Ichiro TatsunoCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Atsuhito SaikiCenter for Diabetes, Endocrine and Metabolism, Toho University Sakura Medical Center, Chiba, Japan.
Toho University · JPChiba Prefectural University of Health Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLaparoscopic sleeve gastrectomy (LSG) significantly increases high-density lipoprotein cholesterol (HDL-C) and lipoprotein lipase (LPL) in pre-heparin serum (pre-heparin LPL levels). LPL is a regulator of serum triglyceride (TG) and HDL-C production; this may be the mechanism for HDL-C increase after LSG. This study aimed to elucidate the mechanism of increase in HDL-C levels by examining the relationship between changes in serum HDL-C levels and LPL after LSG.

methodsWe retrospectively reviewed 104 obese patients, who underwent LSG and were followed up for 12 months. We analyzed the relationship between changes in serum HDL-C levels and various clinical parameters after LSG.

resultsA significant decrease was observed in the patients' BMI and serum TG levels after LSG. Conversely, HDL-C levels and pre-heparin LPL levels were significantly increased after LSG. Simple linear regression showed that changes in HDL-C levels were significantly correlated with total weight loss percentage, change in TG levels, abdominal fat areas, and pre-heparin LPL levels. Additionally, the multiple regression model revealed that a decrease in TG levels and an increase in pre-heparin LPL levels were correlated with increased HDL-C levels after LSG. DISCUSSION/

conclusionThese results show that a decrease in TG levels and an increase in LPL are mechanisms for increased HDL-C levels after LSG.

Indexed as

LaparoscopyLipoprotein LipaseCholesterol, HDLGastrectomyHumansLipaseRetrospective StudiesTriglyceridesCholesterol, HDLLipaseLipoprotein LipaseTriglyceridesHigh-density lipoprotein cholesterolLaparoscopic sleeve gastrectomyLipoprotein lipaseObesityTriglyceride

Identifiers

PMID34634786
PMCPMC8739375
OpenAlexW3207858793

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.