Evidence map›Paper›PMID 34634530›Full record

ArticleJournal of pharmaceutical and biomedical analysis2022

Development and application of immunoassays for rapid quality control of the antimalarial drug combination artesunate-mefloquine.

Jingqi Qian, Mian Wang, Man Zhang, Rui Feng, Jiaqi Zhang, Chencheng Ye, Baomin Wang, Liwang Cui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical and biomedical analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Optimization of HPLC-MS/MS method for determination of antimalarial adulterants in herbal products.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Jingqi QianCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
Mian WangCollege of Food and Bioengineering, Xihua University, Chengdu 610039, China.
Man ZhangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
Rui FengCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
Jiaqi ZhangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
Chencheng YeCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China.
Baomin WangCollege of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, China. Electronic address: wbaomin@263.net.
Liwang CuiDepartment of Internal Medicine, Morsani College of Medicine, University of South Florida, 3720 Spectrum Boulevard, Suite 304, Tampa, FL 33612, USA. Electronic address: liwangcui@usf.edu.
China Agricultural University · CNUniversity of South Florida · USXihua University · CN

Funding

Southeast Asia Malaria Research CenterU19AI089672 · NIAID · UNIVERSITY OF SOUTH FLORIDA · PI CUI, LIWANG · 2010 to 2023
$28.9M
NIAID NIH HHS U19 AI089672
6 · The paper itself

Abstract

Artesunate-mefloquine is one of the commonly-used artemisinin-based combination therapies (ACTs). Given the significance of drug quality in the management of malaria cases, the objective of this study was to develop antibody-based assays as the point-of-care (POC) tests for monitoring the quality of this ACT. Using mefloquine conjugated to a carrier protein as the immunogen, we selected a specific monoclonal antibody (mAb) against mefloquine with no cross-reactivity to other antimalarial drugs. Using this mAb, we developed a direct competitive enzyme-linked immunosorbent assay (dcELISA) and a lateral flow immunoassay (LFIA) to measure the mefloquine contents. The dcELISA for mefloquine showed a 50% inhibitory concentration (IC

Indexed as

AntimalarialsArtesunateDrug Therapy, CombinationImmunoassayMefloquineQuality ControlAntimalarialsArtesunateMefloquineArtesunate-mefloquineCombination dipstickImmunoassayMonoclonal antibodyQuality control

Identifiers

PMID34634530
PMCPMC9511660
OpenAlexW3196488778

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.