Trial reportOphthalmology2022
Ocular Biometric Risk Factors for Progression of Primary Angle Closure Disease: The Zhongshan Angle Closure Prevention Trial.
Trial report in Ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 79 citations in OpenAlex.
- Peripheral Iridectomy With Goniosynechialysis and Goniotomy vs Trabeculectomy for Advanced PACG: A Randomized Clinical Trial.JAMA ophthalmology · 2025Trial
- Role of Static and Dynamic Ocular Biometrics Measured in the Dark and Light as Risk Factors for Angle Closure Progression.American journal of ophthalmology · 2023Trial
- Risk-Stratified Interventional Management and Surgical Decision-Making in Primary Glaucoma.Biomedicines · 2026Review
- Quantitative Assessment of Anterior Segment OCT Parameters and Their Association with Intraocular Pressure in Primary Angle-Closure Disease.Diagnostics (Basel, Switzerland) · 2026Article
- PACS plus stratification of acute angle closure glaucoma cases: a retrospective analysis.Eye (London, England) · 2026Article
- Quadrant-specific assessment of anterior chamber angles in primary angle-closure suspects using anterior segment-OCT: a cross-sectional observational study.BMC ophthalmology · 2026Observational
- Automated iridocorneal angle classification using a multimodal large language model.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Comparative Study of Accommodative Function and Binocular Vision in Patients With Primary Angle-Closure Disease.The Kaohsiung journal of medical sciences · 2026Article
- Risk prediction in primary angle closure suspects: current perspectives.Annals of translational medicine · 2026Article
- Differences in Screening Indicator Performance for Primary Angle Closure and Primary Angle Closure Diseases: The Handan Eye Study.Ophthalmology science · 2026Article
- Results of ocular biometry from a population-based study in detecting angle-closure disease in a clinical setting.Indian journal of ophthalmology · 2026Article
- Predictors of visual field progression in acute and primary angle-closure disease: role of posture-related IOP changes and anterior segment structure.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Differences of anterior segment features in fellow eyes of primary angle closure glaucoma and healthy eyes.Scientific reports · 2026Article
- Mannitol plus pilocarpine for primary acute angle-closure glaucoma: efficacy and safety analysis.American journal of translational research · 2026Article
- Effect of mydriasis on anterior segment biometric parameters of patients with age-related cataracts.BMC ophthalmology · 2025Article
- Acute Angle Closure Incidence in a Large Countywide Safety Net Teleretinal Screening Program.JAMA ophthalmology · 2025Article
- Determinative role of anterior segment optical coherence tomography bioparameters in the pathogenesis of asymmetrical primary angle closure disease.BMC ophthalmology · 2025Article
- Longitudinal Trends in Resource Utilization Associated With Newly Diagnosed Primary Angle Closure Glaucoma in the United States.Journal of glaucoma · 2025Article
- Risk factor stratification in early-onset primary angle closure disease.Eye (London, England) · 2025Observational
- Proposed Nomenclature for Landmarks in Anterior-Segment OCT: The APOSTEL-AS Panel Consensus.JAMA ophthalmology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 4 countries.
Funding
Abstract
purposeTo assess baseline ocular biometric risk factors for progression from primary angle closure suspect (PACS) to primary angle closure (PAC) or acute angle closure (AAC).
designProspective, observational study.
participantsSix hundred forty-three mainland Chinese with untreated PACS.
methodsParticipants underwent baseline clinical examinations, including gonioscopy, anterior segment OCT (AS-OCT) imaging, and A-scan ultrasound biometry as part of the Zhongshan Angle Closure Prevention (ZAP) Trial. Primary angle closure suspect was defined as an inability to visualize pigmented trabecular meshwork in 2 or more quadrants based on static gonioscopy. Primary angle closure was defined as development of intraocular pressure above 24 mmHg or peripheral anterior synechiae. Progression was defined as development of PAC or an AAC attack. Multivariable logistic regression models were developed to assess biometric risk factors for progression.
main outcome measuresSix-year progression from PACS to PAC or AAC.
resultsSix hundred forty-three untreated eyes (609 nonprogressors, 34 progressors) of 643 participants were analyzed. In a multivariable model with continuous parameters, narrower horizontal angle opening distance of 500 μm from the scleral spur (AOD
conclusionsOcular biometric measurements can help to risk-stratify patients with early angle closure for more severe disease. Anterior segment OCT measurements of biometric parameters describing the angle and iris are predictive of progression from PACS to PAC or AAC, whereas gonioscopy grades are not.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.