Evidence map›Paper›PMID 34634286›Full record

ArticleToxicology and applied pharmacology2021

Lung developmental is altered after inhalation exposure to various concentrations of calcium arsenate.

Binh Chau, Mark L Witten, Doug Cromey, Yin Chen, R Clark Lantz

Open access · greenAbstract read
In one paragraph

Article in Toxicology and applied pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Binh ChauDepartment of Cellular & Molecular Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, United States of America. Electronic address: bchau@email.arizona.edu.
Mark L WittenPhoenix Biometrics, Inc., Tucson, AZ 85710, United States of America.
Doug CromeyDepartment of Cellular & Molecular Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, United States of America. Electronic address: dcromey@arizona.edu.
Yin ChenDepartment of Pharmacology and Toxicology, University of Arizona College of Pharmacy, United States of America. Electronic address: ychen@pharmacy.arizona.edu.
R Clark LantzDepartment of Cellular & Molecular Medicine, University of Arizona College of Medicine, Tucson, AZ 85719, United States of America. Electronic address: lantz@email.arizona.edu.
University of Arizona · US

Funding

TRANSPORT OF TRACE METALS IN A POLLUTED AQUIFERP42ES004940 · NIEHS · UNIVERSITY OF ARIZONA · PI Xinxin Ding · 1990 to 2026
$68.1M
SOUTHWEST ENVIRONMENTAL HEALTH SCIENCES CENTERP30ES006694 · NIEHS · UNIVERSITY OF ARIZONA · PI DEAN BILLHEIMER · 1994 to 2026
$36.7M
Fungal Asthma and Lung Innate ImmunityR01AI149754 · NIAID · UNIVERSITY OF ARIZONA · PI CHEN, YIN · 2020 to 2024
$2.6M
Arsenic exposure, CC16 and its effect on pulmonary functionR01ES027013 · NIEHS · UNIVERSITY OF ARIZONA · PI CHEN, YIN, LANTZ, ROBERT CLARK · 2017 to 2021
$1.7M
NIAID NIH HHS R01 AI149754NIEHS NIH HHS P30 ES006694NIEHS NIH HHS P42 ES004940NIEHS NIH HHS R01 ES027013
6 · The paper itself

Abstract

Exposure to dust from active and abandoned mining operations may be a very significant health hazard, especially to sensitive populations. We have previously reported that inhalation of real-world mine tailing dusts during lung development can alter lung function and structure in adult male mice. These real-world dusts contain a mixture of metal(loid)s, including arsenic. To determine whether arsenic in inhaled dust plays a role in altering lung development, we exposed C57Bl/6 mice to a background dust (0 arsenic) or to the background dust containing either 3% or 10% by mass, calcium arsenate. Total level of exposure was kept at 100 μg/m

Indexed as

Prenatal Exposure Delayed EffectsAge FactorsAirway RemodelingAirway ResistanceAnimalsArsenatesBronchoconstrictionCalcium CompoundsCollagenDown-RegulationDustFemaleGestational AgeInhalation ExposureLungMaleArsenatescalcium arsenateCalcium CompoundsCollagenDustScgb1a1 protein, mouseUteroglobinLung developmentLung diseaseSimulated mine tailings dust

Identifiers

PMID34634286
PMCPMC8572171
OpenAlexW3205584620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.