ArticleIEEE transactions on bio-medical engineering2022
Characterization of Anti-Angiogenic Chemo-Sensitization via Longitudinal Ultrasound Localization Microscopy in Colorectal Carcinoma Tumor Xenografts.
Article in IEEE transactions on bio-medical engineering, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05754814 (SUper-Resolution Ultrasound Imaging of Erythrocytes), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
SUper-Resolution Ultrasound Imaging of Erythrocytes (SURE) in Normal and Malignant Lymph Nodes
Who cites it
9 citing papers in PubMed, 20 citations in OpenAlex.
- Human lymph node microvascular imaging using a fast contrast-free super-resolution ultrasound technique.Scientific reports · 2025Article
- Differentiation of benign and malignant breast lesions by ultrasound localization microscopy.Insights into imaging · 2025Article
- Focal liver lesions: multiparametric microvasculature characterization via super-resolution ultrasound imaging.European radiology experimental · 2024Observational
- Inspiring a convergent engineering approach to measure and model the tissue microenvironment.Heliyon · 2024Review
- Superharmonic and Microultrasound Imaging With Plane Wave Beamforming Techniques.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Contrast-Free Super-Resolution Power Doppler (CS-PD) Based on Deep Neural Networks.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2023Article
- Super-resolution ultrasound microvascular imaging: Is it ready for clinical use?Zeitschrift fur medizinische Physik · 2023Review
- Localization Free Super-Resolution Microbubble Velocimetry Using a Long Short-Term Memory Neural Network.IEEE transactions on medical imaging · 2023Article
- Fundamentals of Bowel Cancer for Biomedical Engineers.Annals of biomedical engineering · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 2 countries.
Funding
Abstract
objectiveSuper-resolution ultrasound localization microscopy (ULM) has unprecedented vascular resolution at clinically relevant imaging penetration depths. This technology can potentially screen for the transient microvascular changes that are thought to be critical to the synergistic effect(s) of combined chemotherapy-antiangiogenic agent regimens for cancer.
methodsIn this paper, we apply this technology to a high-throughput colorectal carcinoma xenograft model treated with either the antiangiogenic agent sorafenib, FOLFOX-6 chemotherapy, a combination of the two treatments, or vehicle control.
resultsLongitudinal ULM demonstrated morphological changes in the antiangiogenic treated cohorts, and evidence of vascular disruption caused by chemotherapy. Gold-standard histological measurements revealed reduced levels of hypoxia in the sorafenib treated cohort for both of the human cell lines tested (HCT-116 and HT-29). Therapy resistance was associated with an increase in tumor vascular fractal dimension as measured by a box-counting technique on ULM images.
conclusionThese results imply that the morphological changes evident on ULM signify a functional change in the tumor microvasculature, which may be indicative of chemo-sensitivity. SIGNIFICANCE: ULM provides additional utility for tumor therapy response evaluation by offering a myriad of morphological and functional quantitative indices for gauging treatment effect(s).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.