Evidence map›Paper›PMID 34633878›Full record

ArticleCell transplantation

Stem Cells from Human Exfoliated Deciduous teeth Promote Hair Regeneration in Mouse.

Xiaoshuang Zhang, Tong Lei, Peng Chen, Lei Wang, Jian Wang, Donghui Wang, Wenhuan Guo, Yabin Zhou, Quanhai Li, Hongwu Du

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Review
  9. Morphogenesis, Growth Cycle and Molecular Regulation of Hair Follicles.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Xiaoshuang ZhangDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Tong LeiDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Peng ChenBeijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases, Experimental Research Center, China Academy of Chinese Medical Sciences, Dongcheng District, Beijing, China.
Lei WangDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Jian WangDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Donghui WangDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Wenhuan GuoDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Yabin ZhouDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.
Quanhai LiCell Therapy Laboratory, the First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Hongwu DuDaxing Research Institute, University of Science and Technology Beijing, Beijing, China.ORCID 0000-0001-7772-8444
University of Science and Technology Beijing · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNHebei Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stem cells in different types may interact with each other to maintain homeostasis or growth and the interactions are complicated and extensive. There is increasing evidence that mesenchymal-epithelial interactions in early morphogenesis stages of both tooth and hair follicles show many similarities. In order to explore whether stem cells from one tissue could interact with cells from another tissue, a series of experiments were carried out. Here we successfully extracted and identified stem cells from human exfoliated deciduous teeth (SHED) of 8-12 years old kids, and then found that SHED could promote hair regeneration in a mouse model. In vitro, SHED shortened the hair regeneration cycle and promoted the proliferation and aggregation of dermal cells. In vivo, when SHED and skin cells of C57 mice were subcutaneously co-transplanted to nude mice, more hair was formed than skin cells without SHED. To further explore the molecular mechanism, epidermal and dermal cells were freshly extracted and co-cultured with SHED. Then several signaling molecules in hair follicle regeneration were detected and we found that the expression of Sonic Hedgehog (Shh) and Glioma-associated oncogene 1 (Gli1) was up-regulated. It seems that SHED may boost the prosperity of hairs by increase Shh/Gli1 pathway, which brings new perspectives in tissue engineering and damaged tissue repairing.

Indexed as

AnimalsCell ProliferationChildDisease Models, AnimalFemaleHair FollicleHumansMaleMiceMice, NudeRegenerationStem Cell TransplantationTissue EngineeringTooth, Deciduouscell interactionhair regenerationSonic Hedgehogstem cells from human exfoliated deciduous teethtransplantation

Identifiers

PMID34633878
PMCPMC8512255
OpenAlexW3205246752

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.