Evidence map›Paper›PMID 34633849›Full record

ArticleAntimicrobial agents and chemotherapy2022

Investigation of Antiparasitic Activity of 10 European Tree Bark Extracts on Toxoplasma gondii and Bioguided Identification of Triterpenes in

Pierre Darme, Jérémy Spalenka, Jane Hubert, Sandie Escotte-Binet, Laurent Debelle, Isabelle Villena, Charlotte Sayagh, Nicolas Borie, Agathe Martinez, Benjamin Bertaux and 3 more

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The Search for Drugs Derived from Natural Products forCurrent topics in medicinal chemistry · 2024
    Pooled it
  2. Article
  3. Rapid Chemical Profiling ofMolecules (Basel, Switzerland) · 2023
    Article
  4. Evaluation of the Anti-Antibiotics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Frontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Pierre DarmeUniversité de Reims Champagne-Ardenne, ESCAPE EA 7510, Centre Hospitalier de Reims et Université de Reims Champagne-Ardenne, Reims, France.ORCID 0000-0002-8980-8772
Jérémy SpalenkaUniversité de Reims Champagne-Ardenne, ESCAPE EA 7510, Centre Hospitalier de Reims et Université de Reims Champagne-Ardenne, Reims, France.
Jane HubertNatExplore SAS, Prouilly, France.
Sandie Escotte-BinetUniversité de Reims Champagne-Ardenne, ESCAPE EA 7510, Centre Hospitalier de Reims et Université de Reims Champagne-Ardenne, Reims, France.
Laurent DebelleUniversité de Reims Champagne Ardenne, CNRS, MEDyC UMR 7369, Reims, France.
Isabelle VillenaUniversité de Reims Champagne-Ardenne, ESCAPE EA 7510, Centre Hospitalier de Reims et Université de Reims Champagne-Ardenne, Reims, France.
Charlotte SayaghUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Nicolas BorieUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Agathe MartinezUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Benjamin BertauxUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Laurence Voutquenne-NazabadiokoUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Jean-Hugues RenaultUniversité de Reims Champagne-Ardenne, CNRS, ICMR 7312, Reims, France.
Dominique AubertUniversité de Reims Champagne-Ardenne, ESCAPE EA 7510, Centre Hospitalier de Reims et Université de Reims Champagne-Ardenne, Reims, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis is a worldwide parasitosis that affects one-third of the population. People at risk, such as immunocompromised patients (AIDS, chemotherapy treatment) or fetuses (maternal-fetal transmission) can develop severe forms of the disease. The antiparasitic activity of extracts of different polarities (

Indexed as

AlnusToxoplasmaTriterpenesAntiparasitic AgentsHumansPlant BarkPlant ExtractsAntiparasitic AgentsPlant ExtractsTriterpenesAlnus glutinosaantiparasitic agentsapicomplexabarkBetulaceaeToxoplasma gondiitriterpene

Identifiers

PMID34633849
PMCPMC8765260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.