Evidence map›Paper›PMID 34633846›Full record

ArticleAntimicrobial agents and chemotherapy2022

DectiSomes: Glycan Targeting of Liposomal Drugs Improves the Treatment of Disseminated Candidiasis.

Suresh Ambati, Tuyetnhu Pham, Zachary A Lewis, Xiaorong Lin, Richard B Meagher

Open access · hybridAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Safety and efficacy of echinocandin antifungal agents inAntimicrobial agents and chemotherapy · 2026
    Article
  4. Altering the ligand specificity of DectiSomes.The Journal of biological chemistry · 2025
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Targeted Delivery of Antifungal Liposomes toJournal of fungi (Basel, Switzerland) · 2022
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Suresh AmbatiDepartment of Genetics, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Tuyetnhu PhamDepartment of Microbiology, University of Georgiagrid.213876.9, Athens, Georgia, USA.
Zachary A LewisDepartment of Microbiology, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0002-1735-8266
Xiaorong LinDepartment of Microbiology, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0002-3390-8387
Richard B MeagherDepartment of Genetics, University of Georgiagrid.213876.9, Athens, Georgia, USA.ORCID 0000-0003-3928-8403
University of Georgia · US

Funding

Targeted Pan-Antifungal LiposomesR01AI162989 · NIAID · UNIVERSITY OF GEORGIA · PI Zachary Lewis, Richard Brian Meagher · 2022 to 2026
$2.6M
Antifungal Liposomes Targeted to Cell Wall MannansR21AI148890 · NIAID · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN · 2020 to 2021
$415k
Systematic investigation of GPI-anchored mannoproteins in Cryptococcus neoformansR21AI150641 · NIAID · UNIVERSITY OF GEORGIA · PI LIN, XIAORONG · 2020 to 2021
$415k
Antifungal ImunoliposomesR21AI144498 · NIAID · UNIVERSITY OF GEORGIA · PI MEAGHER, RICHARD BRIAN · 2019 to 2020
$415k
NIAID NIH HHS R01 AI162989NIAID NIH HHS R21 AI144498NIAID NIH HHS R21 AI148890NIAID NIH HHS R21 AI150641
6 · The paper itself

Abstract

Candida albicans causes life-threatening disseminated candidiasis. Individuals at greatest risk have weakened immune systems. An outer cell wall, exopolysaccharide matrix, and biofilm rich in oligoglucans and oligomannans help

Indexed as

CandidiasisLiposomesAnimalsAntifungal AgentsCandida albicansMammalsMicePolysaccharidesAntifungal AgentsLiposomesPolysaccharidesAmBisomeamphotericin BanidulafunginCandidaCandida albicanscandidiasisDectinDectiSomestargeted delivery of antifungals

Identifiers

PMID34633846
PMCPMC8765427
OpenAlexW3206425275

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.