Evidence map›Paper›PMID 34633603›Full record

SynthesisCerebellum (London, England)2022

Cerebellar Symptoms in Gluten Sensitivity: a Systematic Review of the Effect of a Gluten-Free Diet on Brain Imaging.

Juliana J Schmidt, Julio C Tolentino, Glenda C B Lacerda, Guilherme J Schmidt, Eelco van Duinkerken, Sergio L Schmidt

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Cerebellum (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Juliana J SchmidtDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil. julianaschmidtjaneiro@gmail.com.
Julio C TolentinoDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil.
Glenda C B LacerdaDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil.
Guilherme J SchmidtDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil.
Eelco van DuinkerkenDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil.
Sergio L SchmidtDepartment of Neurology, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Zip Code 202709001, Brazil.
Universidade Federal do Estado do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebellar manifestations have been described in patients with gluten sensitivity (GS)-related disorders. A better understanding of the neurological manifestations of GS requires the use of neuroimaging techniques. We performed a systematic review on neuroimaging findings in GS patients with cerebellar symptoms. We also included a specific search on neuroimaging findings in GS patients with cerebellar manifestations on a gluten-free diet (GFD). PubMed, Embase, and Bireme were systematically searched to identify studies assessing neuroimaging features of adults with cerebellar manifestations and GS with or without enteropathy on a GFD. Ten studies with a total of 222 adult-GS patients were included. Magnetic resonance imaging was used in 100% of the studies. Cerebellar atrophy was evaluated in 7 studies and observed in 63% of the patients. White matter abnormalities were described in 2 studies. Single-photon emission computed tomography was used in 2 studies, and decreased cerebellar perfusion was detected in 92% of the included patients. No study employed nuclear medicine after the start of GFD. Magnetic resonance spectroscopy (MRS) was performed in 2 studies before and after GFD. An increase in the Naa/Cr ratio in cerebellar vermis was seen in 98% of the cases on a strict GFD. Cerebellar atrophy was found to be a prevalent condition in GS patients. MRS demonstrated to be useful in the follow-up of GS patients with cerebellar manifestations on a GFD. Prospective studies using nuclear medicine imaging are needed to study brain changes in GS patients on a GFD.

Indexed as

Celiac DiseaseDiet, Gluten-FreeAdultAtrophyCerebellumGlutensHumansNeuroimagingProspective StudiesGlutensCerebellar symptomsGluten-free dietGluten sensitivityNeuroimaging

Identifiers

PMID34633603
OpenAlexW3205385579

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.