Evidence map›Paper›PMID 34633522›Full record

ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2022

Long-term clinical outcome and satisfaction survey in patients with neurotrophic keratopathy after treatment with cenegermin eye drops or amniotic membrane transplantation.

Marta Sacchetti, Chiara Komaiha, Alice Bruscolini, Giuseppe Maria Albanese, Marco Marenco, Rossella Anna Maria Colabelli Gisoldi, Augusto Pocobelli, Alessandro Lambiase

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Marta SacchettiDepartment of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
Chiara KomaihaAzienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
Alice BruscoliniDepartment of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
Giuseppe Maria AlbaneseDepartment of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
Marco MarencoDepartment of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy.
Rossella Anna Maria Colabelli GisoldiAzienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
Augusto PocobelliAzienda Ospedaliera San Giovanni Addolorata, Rome, Italy.
Alessandro LambiaseDepartment of Sense Organs, University Sapienza of Rome, Viale del Policlinico, 155, 00161, Rome, Italy. alessandro.lambiase@uniroma1.it.ORCID http://orcid.org/0000-0002-8974-991X
Policlinico Umberto I · ITAzienda Ospedaliera San Giovanni Addolorata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeNeurotrophic keratopathy (NK) is a degenerative corneal disease caused by damage of trigeminal innervation. The purpose of this study is to evaluate the clinical outcomes and patient-reported satisfaction of treatment with amniotic membrane transplantation (AMT) or cenegermin eye drops in patients with NK.

methodsClinical charts of patients with NK treated with AMT (group A) or cenegermin eye drops (group B), with at least 12 months of follow-up, were reviewed for demographics, medical history, corneal healing, and disease recurrence. Patient satisfaction was evaluated by a newly developed questionnaire investigating patient's appreciation of treatment of NK (2 items) and satisfaction with NK treatment outcomes (5 items).

resultsAt the end of treatment, complete corneal healing was observed in 13/15 (86%) patients in group A and in 23/24 (96%) in group B. At 12 months follow-up, 6/13 patients (46%) in group A and 3/23 patients (13%) in group B showed recurrence of NK (p = 0.037). Survival analysis showed that group B remained recurrence free for a significantly longer period of time than the group A (p = 0.028). Patients in group B showed a significantly higher satisfaction when compared with patients in group A (total score: 65.7 ± 15.7 vs 47.4 ± 12.8, p = 0.003), both in terms of patients' appreciation of treatment (78.3 ± 15.9 vs 52.2 ± 30, p = 0.020) and satisfaction with treatment outcomes (60.7 ± 21 vs 45.4 ± 13.3, p = 0.037).

conclusionsTreatment of NK with cenegermin was associated with long-term maintenance of corneal integrity and a higher degree of patient satisfaction.

Indexed as

AmnionCorneal Dystrophies, HereditaryCorneaHumansNerve Growth FactorOphthalmic SolutionsPatient SatisfactionPersonal SatisfactionRecombinant ProteinsSurveys and QuestionnairesTreatment OutcomecenegerminNerve Growth FactorOphthalmic SolutionsRecombinant ProteinsAmniotic membrane transplantationCenegerminCorneal ulcersNeurotrophic keratitisRecombinant human nerve growth factor

Identifiers

PMID34633522
PMCPMC8850233
OpenAlexW3205252098

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.