Evidence map›Paper›PMID 34633509›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2021

Targeted optical fluorescence imaging: a meta-narrative review and future perspectives.

H M Schouw, L A Huisman, Y F Janssen, R H J A Slart, R J H Borra, A T M Willemsen, A H Brouwers, J M van Dijl, R A Dierckx, G M van Dam and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed.

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  18. The wings of progress: technological and radiopharmaceutical innovations in nuclear medicine.European journal of nuclear medicine and molecular imaging · 2024
    Article
  19. How to objectively evaluate the impact of image-guided surgery technologies.European journal of nuclear medicine and molecular imaging · 2024
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

H M Schouw *Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-8996-4353
L A Huisman *Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Y F JanssenDepartment of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1271-3780
R H J A SlartDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
R J H BorraDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-8072-1243
A T M WillemsenDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
A H BrouwersDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-2698-1516
J M van DijlDepartment of Medical Microbiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-5688-8438
R A DierckxDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
G M van DamDepartment of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-7248-8696
W SzymanskiDepartment of Radiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0002-9754-9248
H H Boersma *Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-1892-9830
S Kruijff *Department of Surgery, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. s.kruijff@umcg.nl.ORCID http://orcid.org/0000-0002-5151-7320

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this review is to give an overview of the current status of targeted optical fluorescence imaging in the field of oncology, cardiovascular, infectious and inflammatory diseases to further promote clinical translation.

methodsA meta-narrative approach was taken to systematically describe the relevant literature. Consecutively, each field was assigned a developmental stage regarding the clinical implementation of optical fluorescence imaging.

resultsOptical fluorescence imaging is leaning towards clinical implementation in gastrointestinal and head and neck cancers, closely followed by pulmonary, neuro, breast and gynaecological oncology. In cardiovascular and infectious disease, optical imaging is in a less advanced/proof of concept stage.

conclusionTargeted optical fluorescence imaging is rapidly evolving and expanding into the clinic, especially in the field of oncology. However, the imaging modality still has to overcome some major challenges before it can be part of the standard of care in the clinic, such as the provision of pivotal trial data. Intensive multidisciplinary (pre-)clinical joined forces are essential to overcome the delivery of such compelling phase III registration trial data and subsequent regulatory approval and reimbursement hurdles to advance clinical implementation of targeted optical fluorescence imaging as part of standard practice.

Indexed as

FluorescenceOptical ImagingCardiologyForecastingHumansInfectious Disease MedicineInflammationMedical OncologyCardiovascular diseaseFluorescenceInfectious diseaseOncologyOptical fluorescence imaging

Identifiers

PMID34633509
PMCPMC8566445

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.