Evidence map›Paper›PMID 34633493›Full record

ArticlePediatric cardiology2022

Worse Hospital Outcomes for Children and Adults with COVID-19 and Congenital Heart Disease.

Danielle D Strah, Katie A Kowalek, Kevin Weinberger, Jenny Mendelson, Andrew W Hoyer, Scott E Klewer, Michael D Seckeler

Abstract read
In one paragraph

Article in Pediatric cardiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Impacts of COVID-19 on pediatric patients with congenital heart disease: a small systematic and integrative literature review.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2025
    Pooled it
  3. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.Journal of the Pediatric Infectious Diseases Society · 2024
    Pooled it
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  15. Risk Factors for Pediatric Critical COVID-19: A Systematic Review and Meta-Analysis.medRxiv : the preprint server for health sciences · 2024
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  20. Arrhythmia and COVID-19 in children.Clinical and experimental pediatrics · 2023
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Danielle D StrahDepartment of Pediatrics, University of Arizona, Tucson, USA.
Katie A KowalekDepartment of Pediatrics (Critical Care), University of Arizona, Tucson, USA.
Kevin WeinbergerDepartment of Pediatrics, University of Arizona, Tucson, USA.
Jenny MendelsonDepartment of Pediatrics (Critical Care), University of Arizona, Tucson, USA.
Andrew W HoyerDepartment of Pediatrics (Cardiology), University of Arizona, 1501 N. Campbell Ave, PO Box 245073, Tucson, AZ, 85724, USA.
Scott E KlewerDepartment of Pediatrics (Cardiology), University of Arizona, 1501 N. Campbell Ave, PO Box 245073, Tucson, AZ, 85724, USA.
Michael D SeckelerDepartment of Pediatrics (Cardiology), University of Arizona, 1501 N. Campbell Ave, PO Box 245073, Tucson, AZ, 85724, USA. mseckeler@peds.arizona.edu.ORCID http://orcid.org/0000-0001-9013-5723

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of the current study is to investigate hospitalization outcomes of COVID-19 positive children and adults with moderate or severe congenital heart disease to children and adults without congenital heart disease. Retrospective review using the Vizient Clinical Data Base for admissions of patients with an ICD-10 code for COVID-19 from April 2020 to March 2021. Admissions with COVID-19 and with and without moderate or severe congenital heart disease (CHD) were stratified into pediatric (< 18 years) and adult (≥ 18 years) and hospital outcomes were compared. There were 9478 pediatric COVID-19 admissions, 160 (1.7%) with CHD, and 658,230 adult COVID-19 admissions, 389 (0.06%) with CHD. Pediatric admissions with COVID-19 and CHD were younger (1 vs 11 years), had longer length of stay (22 vs 6 days), higher complication rates (6.9 vs 1.1%), higher mortality rates (3.8, 0.8%), and higher costs ($54,619 vs 10,731; p < 0.001 for all). Adult admissions with COVID-19 and CHD were younger (53 vs 64 years, p < 0.001), had longer length of stay (12 vs 9 days, p < 0.001), higher complication rates (8 vs 4.8%, p = 0.003), and higher costs ($23,551 vs 13,311, p < 0.001). This appears to be the first study to report the increased hospital morbidities and costs for patients with CHD affected by COVID-19. Our hope is that these findings will help counsel patients moving forward during the pandemic.

Indexed as

COVID-19Heart Defects, CongenitalAdultChildHospitalizationHospitalsHumansLength of StayCongenital heart diseaseCOVID-19FontanHospital outcomesTetralogy of FallotTransposition of the great arteries

Identifiers

PMID34633493
PMCPMC8503707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.