Evidence map›Paper›PMID 34633469›Full record

ArticleJournal of molecular medicine (Berlin, Germany)2021

Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress-mediated hippocampal damage after myocardial infarction.

Tsung-Ming Lee, Cheng-Che Lee, Horng-Jyh Harn, Tzyy-Wen Chiou, Ming-Hsi Chuang, Chun-Hung Chen, Chi-Hsuan Chuang, Po-Cheng Lin, Shinn-Zong Lin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular medicine (Berlin, Germany), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Tsung-Ming LeeGood Heart Clinic, Tainan, Taiwan.ORCID 0000-0002-3487-8749
Cheng-Che LeeKang-Ming Senior High School, Tainan, Taiwan.
Horng-Jyh HarnBioinnovation Center, Tzu Chi Foundation, Department of Pathology, Buddhist Tzu Chi General Hospital, Tzu Chi University, Hualien, Taiwan.
Tzyy-Wen ChiouDepartment of Life Science and Graduate Institute of Biotechnology, National Dong Hwa University, Hualien, Taiwan.
Ming-Hsi ChuangDepartment of Technology Management, Chung Hua University, Hsinchu City, Taiwan.
Chun-Hung ChenGwo Xi Stem Cell Applied Technology, Hsinchu, Taiwan.
Chi-Hsuan ChuangGenomics Research Center, Academia Sinica, Taipei, Taiwan.
Po-Cheng LinGwo Xi Stem Cell Applied Technology, Hsinchu, Taiwan.
Shinn-Zong LinBioinnovation Center, Tzu Chi Foundation, Department of Neurosurgery, Buddhist Tzu Chi General Hospital, Tzu Chi University, No.707, Sec. 3, Chung Yang Rd. 970, Hualien, Taiwan. shinnzong@yahoo.com.tw.
Stem Cell Technology (Taiwan) · TWTzu Chi University · TWGenomics Research Center, Academia Sinica · TWNational Dong Hwa University · TWUniversity of Kang Ning · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cognitive impairment is a serious side effect of post-myocardial infarction (MI) course. We have recently demonstrated that human adipose-derived stem cells (hADSCs) ameliorated myocardial injury after MI by attenuating reactive oxygen species (ROS) levels. Here, we studied whether the beneficial effects of intramyocardial hADSC transplantation can extend to the brain and how they may attenuate cognitive dysfunction via modulating ROS after MI. After coronary ligation, male Wistar rats were randomized via an intramyocardial route to receive either vehicle, hADSC transplantation (1 × 10

Indexed as

Stem Cell TransplantationAdipose TissueAnimalsbeta 2-MicroglobulinBrainCognitive DysfunctionHumansMaleMyocardial InfarctionMyocardiumOxidative StressRatsRats, WistarStem CellsSuperoxidesB2M protein, humanbeta 2-MicroglobulinSuperoxidesCognitive functionHippocampusHuman adipose-derived stem cellsMyocardial infarctionPassive avoidance testReactive oxygen species

Identifiers

PMID34633469
PMCPMC8599314
OpenAlexW3178469368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.