ArticlePain medicine (Malden, Mass.)2022
Electroencephalography Signatures for Conditioned Pain Modulation and Pain Perception in Nonspecific Chronic Low Back Pain-An Exploratory Study.
Article in Pain medicine (Malden, Mass.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Brain compensatory mechanisms in depression and memory complaints in fibromyalgia: the role of theta oscillatory activity.Pain medicine (Malden, Mass.) · 2024Trial
- Green light exposure reduces central sensitization in cats with osteoarthritis-associated somatosensory impairment.iScience · 2026Article
- Chronic pain and oscillatory neuroplasticity: Review on impaired compensatory network responses in resting-state electroencephalography.Brain network disorders · 2026Article
- Normative Modeling of EEG Complexity Reveals Cortical Rigidity Associated with Pain Severity in Chronic Pain.Journal of pain research · 2026Article
- Exploring the interplay between pain processing mechanisms, psychosocial factors, and functional outcomes in patients with chronic low back pain: an exploratory study.Annals of medicine · 2025Article
- The alternation of neural oscillations during dual task standing in older adults with low back pain.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2025Article
- Analysis of Forward Trunk Bending in Women with Chronic Low Back Pain Undergoing Functional Training.Journal of clinical medicine · 2025Article
- Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review.BMJ neurology open · 2025Article
- Advances and challenges in neuroimaging-based pain biomarkers.Cell reports. Medicine · 2024Review
- Adaptive and Compensatory Neural Signatures in Fibromyalgia: An Analysis of Resting-State and Stimulus-Evoked EEG Oscillations.Biomedicines · 2024Article
- Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study.Life (Basel, Switzerland) · 2023Article
- Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.Frontiers in neuroscience · 2023Article
- In search of a composite biomarker for chronic pain by way of EEG and machine learning: where do we currently stand?Frontiers in neuroscience · 2023Review
- Temporal Summation in Fibromyalgia Patients: Comparing Phasic and Tonic Paradigms.Frontiers in pain research (Lausanne, Switzerland) · 2022Article
- Cerebral peak alpha frequency: Associations with chronic pain onset and pain modulation.Neurobiology of pain (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
Abstract
Conditioned pain modulation (CPM) can discriminate between healthy and chronic pain patients. However, its relationship with neurophysiological pain mechanisms is poorly understood. Brain oscillations measured by electroencephalography (EEG) might help gain insight into this complex relationship.
objectiveTo investigate the relationship between CPM response and self-reported pain intensity in non-specific chronic low back pain (NSCLBP) and explore respective EEG signatures associated to these mechanisms.
designCross-sectional analysis.
participantsThirty NSCLBP patients participated.
methodsSelf-reported low back pain, questionnaires, mood scales, CPM (static and dynamic quantitative sensory tests), and resting surface EEG data were collected and analyzed. Linear regression models were used for statistical analysis.
resultsCPM was not significantly correlated with self-reported pain intensity scores. Relative power of EEG in the beta and high beta bands as recorded from the frontal, central, and parietal cortical areas were significantly associated with CPM. EEG relative power at delta and theta bands as recorded from the central area were significantly correlated with self-reported pain intensity scores while controlling for self-reported depression.
conclusionsFaster EEG frequencies recorded from pain perception areas may provide a signature of a potential cortical compensation caused by chronic pain states. Slower EEG frequencies may have a critical role in abnormal pain processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.