ArticleMolecular biology and evolution2022
Evolutionary Implications of the RNA N6-Methyladenosine Methylome in Plants.
Article in Molecular biology and evolution, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 44 citations in OpenAlex.
- StALKBH10B-Mediated RNA mPlant biotechnology journal · 2026Article
- Identification of Key Sequence Motifs Essential for the Recognition of mBiomolecules · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
- Emerging Orchestrator of Ecological Adaptation: mMolecular ecology · 2025Review
- Machine learning-augmented m6A-Seq analysis without a reference genome.Briefings in bioinformatics · 2025Article
- Review
- Nucleotide-resolution Mapping of RNA N6-Methyladenosine (m6A) modifications and comprehensive analysis of global polyadenylation events in mRNA 3' end processing in malaria pathogenbioRxiv : the preprint server for biology · 2025Article
- Genome-Wide Identification and Expression Analysis of the ALKB Homolog Gene Family in Potato (International journal of molecular sciences · 2024Article
- N6-methyladenosine RNA modification regulates photoperiod sensitivity in cotton.Plant physiology · 2024Article
- Recent advances in the improvement of genetic resistance against disease in vegetable crops.Plant physiology · 2024Review
- Integrative gene duplication and genome-wide analysis as an approach to facilitate wheat reverse genetics: An example in the TaCIPK family.Journal of advanced research · 2024Article
- PRMD: an integrated database for plant RNA modifications.Nucleic acids research · 2024Article
- Methyltransferase-like (METTL) homologues participate inPlant signaling & behavior · 2023Article
- IPOP: An Integrative Plant Multi-omics Platform for Cross-species Comparison and Evolutionary Study.Molecular biology and evolution · 2023Article
- Global hypermethylation of the N6-methyladenosine RNA modification associated with apple heterografting.Plant physiology · 2023Article
- Changes in mBMC plant biology · 2023Article
- N6-methyladenosine RNA modification regulates cotton drought response in a CaPlant biotechnology journal · 2023Article
- The covalent nucleotide modifications within plant mRNAs: What we know, how we find them, and what should be done in the future.The Plant cell · 2023Article
- Recent advances in the plant epitranscriptome.Genome biology · 2023Review
- The characteristics of mRNA mHorticulture research · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epigenetic modifications play important roles in genome evolution and innovation. However, most analyses have focused on the evolutionary role of DNA modifications, and little is understood about the influence of posttranscriptional RNA modifications on genome evolution. To explore the evolutionary significance of RNA modifications, we generated transcriptome-wide profiles of N6-methyladenosine (m6A), the most prevalent internal modification of mRNA, for 13 representative plant species spanning over half a billion years of evolution. These data reveal the evolutionary conservation and divergence of m6A methylomes in plants, uncover the preference of m6A modifications on ancient orthologous genes, and demonstrate less m6A divergence between orthologous gene pairs with earlier evolutionary origins. Further investigation revealed that the evolutionary divergence of m6A modifications is related to sequence variation between homologs from whole-genome duplication and gene family expansion from local-genome duplication. Unexpectedly, a significant negative correlation was found between the retention ratio of m6A modifications and the number of family members. Moreover, the divergence of m6A modifications is accompanied by variation in the expression level and translation efficiency of duplicated genes from whole- and local-genome duplication. Our work reveals new insights into evolutionary patterns of m6A methylomes in plant species and their implications, and provides a resource of plant m6A profiles for further studies of m6A regulation and function in an evolutionary context.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.