ArticleEMBO molecular medicine2021
A microRNA signature that correlates with cognition and is a target against cognitive decline.
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Article in EMBO molecular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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46citing papers in PubMed, 1 pooled it
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46 citing papers in PubMed, 1 synthesis or guideline pooled it.
- DNA methylation signatures of bilateral hippocampal volume, asymmetry and atrophy: a cross-omics analysis in the general population.EBioMedicine · 2026Pooled it
- The role of microRNAs in executive functions: a comprehensive review and bioinformatics analysis of human and animal studies.Molecular psychiatry · 2026Review
- Blood-derived microRNA signatures associated with hippocampal structure and atrophy rate: findings from the Rhineland Study.Molecular psychiatry · 2026Article
- Peripheral and Central miRNA Signatures in Alzheimer's Disease: Tissue-Specific Variability, Sex-Associated Differences, and Implications for Blood-Based Biomarkers.International journal of molecular sciences · 2026Review
- RBAD: The first database dedicated alterations of blood RNA in individuals with Alzheimer's disease and their clinical relevance.Neural regeneration research · 2026Article
- Hippocampal small RNAs from patients with schizophrenia induce specific cognitive and neural phenotypes in mice.Cell death discovery · 2026Article
- miRNA dysregulation in depression: unraveling the interplay between neuroplasticity, HPA axis dysfunction, and neuroinflammation.Metabolic brain disease · 2025Review
- miR-146a Regulates Neuroinflammation and Immune Cell Function in Neurodegenerative Diseases.Current medical science · 2025Review
- MiR-7a-Klf4 axis as a regulator and therapeutic target of neuroinflammation and ferroptosis in Alzheimer's disease.NAR molecular medicine · 2025Article
- MicroRNA Expression and Neurocognitive Outcomes in Children and Young People With Primary Brain Tumor in Karachi, Pakistan: A Pilot Exploratory Study.Brain tumor research and treatment · 2025Article
- Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure.Non-coding RNA · 2025Article
- Neuroinflammation in Alzheimer disease.Nature reviews. Immunology · 2025Review
- A role for astrocytic miR-129-5p in frontotemporal dementia.Translational psychiatry · 2025Article
- MicroRNAs modulate CaMKIIα/SIRT1 signaling pathway as a biomarker of cognitive ability in adolescents.Brain, behavior, & immunity - health · 2025Article
- Identification ofProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Multisensory gamma stimulation enhances adult neurogenesis and improves cognitive function in male mice with Down Syndrome.PloS one · 2025Article
- Intracranial self-stimulation mitigates spatial task deficits, modifies miR-146a and miR-495 serum levels and restores hippocampal NRF2 levels in a rat model of sporadic Alzheimer's disease.Frontiers in aging neuroscience · 2025Article
- Ketogenic diet and microRNAs: focus on cognitive function.Frontiers in nutrition · 2025Review
- Cutaneous squamous cell carcinoma-derived exosomal MicroRNA-31 acts as an oncogene by targeting the tumor suppressor RhoBTB1.Archives of dermatological research · 2024Article
- The plasma miRNAome in ADNI: Signatures to aid the detection of at-risk individuals.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
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Authors and funding
52 authors.
Md Rezaul IslamDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Lalit KauraniDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Tea BerulavaDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Urs HeilbronnerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Monika BuddeInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Tonatiuh Pena CentenoDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID 0000-0002-9329-8912
Vakthang ElerdashviliDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Maria-Patapia ZafieriouInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-4604-4175
Eva BenitoDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Sinem M SertelDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.
Maria GoldbergDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID 0000-0002-0706-7529
Fanny SennerInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Janos L KalmanInstitute of Psychiatric Phenomics and Genomics (IPPG), University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany.
Susanne BurkhardtDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Anne Sophie OepenDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Mohammad Sadman SakibDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.
Cemil KerimogluDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID 0000-0001-6523-5925
Oliver WirthsDepartment for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-4115-0334
Heike BickeböllerDepartment of Genetic Epidemiology, University Medical Center Göttingen, Göttingen, Germany.
Claudia BartelsDepartment for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Frederic BrosseronGerman Center for Neurodegenerative Diseases, Bonn, Germany.ORCID 0000-0003-3137-7516
Katharina BuergerGerman Center for Neurodegenerative Diseases (DZNE, Munich), Munich, Germany.
Nicoleta-Carmen CosmaDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-2656-8046
Klaus FliessbachGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Michael T HenekaGerman Center for Neurodegenerative Diseases, Bonn, Germany.ORCID 0000-0003-4996-1630
Daniel JanowitzInstitute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Munich, Germany.
Ingo KilimannGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Luca KleinedamGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Christoph LaskeDepartment of Psychosomatic Medicine, Rostock University Medical Center, Rostock, Germany.
Coraline D MetzgerGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Matthias H MunkSection for Dementia Research, Hertie Institute for Clinical Brain Research and Department of Psychiatry and Psychotherapy, University of Tübingen, Tübingen, Germany.
Robert PerneczkyDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany.ORCID 0000-0003-1981-7435
Oliver PetersDepartment of Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Josef PrillerGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Boris S RauchmannDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany.ORCID 0000-0003-4547-6240
Nina RoyGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Anja SchneiderGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Annika SpottkeGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Eike J SpruthGerman Center for Neurodegenerative Diseases (DZNE), Berlin, Germany.
Stefan TeipelGerman Center for Neurodegenerative Diseases (DZNE), Rostock, Germany.
Maike TscheuschlerDepartment of Psychiatry, Medical Faculty, University of Cologne, Cologne, Germany.
Michael WagnerGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Jens WiltfangDepartment for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0003-1492-5330
Emrah DüzelGerman Center for Neurodegenerative Diseases (DZNE), Magdeburg, Germany.
Frank JessenGerman Center for Neurodegenerative Diseases, Bonn, Germany.
Delcode Study Group
Silvio O RizzoliDepartment of Neuro- and Sensory Physiology, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-1667-7839
Wolfram-Hubertus ZimmermannInstitute of Pharmacology and Toxicology, University Medical Center Göttingen, Göttingen, Germany.
Thomas G SchulzeDepartment for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.
Peter FalkaiDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, München, Germany.
Farahnaz SananbenesiDepartment for Psychiatry and Psychotherapy, University Medical Center Göttingen, Göttingen, Germany.ORCID 0000-0002-2123-7694
Andre FischerDepartment for Epigenetics and Systems Medicine in Neurodegenerative Diseases, German Center for Neurodegenerative Diseases, Göttingen, Germany.ORCID 0000-0001-8546-1161
Funding
No grant is acknowledged in the PubMed record.
Abstract
While some individuals age without pathological memory impairments, others develop age-associated cognitive diseases. Since changes in cognitive function develop slowly over time in these patients, they are often diagnosed at an advanced stage of molecular pathology, a time point when causative treatments fail. Thus, there is great need for the identification of inexpensive and minimal invasive approaches that could be used for screening with the aim to identify individuals at risk for cognitive decline that can then undergo further diagnostics and eventually stratified therapies. In this study, we use an integrative approach combining the analysis of human data and mechanistic studies in model systems to identify a circulating 3-microRNA signature that reflects key processes linked to neural homeostasis and inform about cognitive status. We furthermore provide evidence that expression changes in this signature represent multiple mechanisms deregulated in the aging and diseased brain and are a suitable target for RNA therapeutics.
Indexed as
Alzheimer DiseaseCognitive DysfunctionMicroRNAsBrainCognitionHumansMicroRNAsAlzheimerbiomarkercognitive impairmentmicroRNARNA therapeutics
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