Evidence map›Paper›PMID 34632813›Full record

ArticleAmerican journal of physiology. Renal physiology2021

Salt sensitivity of volume and blood pressure in a mouse with globally reduced ENaC γ-subunit expression.

Evan C Ray, Ashley Pitzer, Tracey Lam, Alexa Jordahl, Ritam Patel, Mingfang Ao, Allison Marciszyn, Aaliyah Winfrey, Yaacov Barak, Shaohu Sheng and 2 more

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Influence of proteolytic cleavage of ENaC's γ subunit upon NaAmerican journal of physiology. Renal physiology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  10. Salt Sensitivity of Blood Pressure in Women.Hypertension (Dallas, Tex. : 1979) · 2023
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Evan C RayDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0003-1491-4869
Ashley PitzerDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.
Tracey LamDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Alexa JordahlDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Ritam PatelDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Mingfang AoDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.
Allison MarciszynDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Aaliyah WinfreyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.
Yaacov BarakDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Magee-Womens Research Institute, Pittsburgh, Pennsylvania.
Shaohu ShengDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-7198-1702
Annet KiraboDepartment of Medicine, Vanderbilt University, Nashville, Tennessee.
Thomas R KleymanDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0002-2413-5415
University of Pittsburgh · USVanderbilt University · US

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI APODACA, GERARD L · 2008 to 2022
$13.4M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Renal and Epithelial Biology Training ProgramT32DK061296 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2002 to 2022
$3.1M
Immune Mechanisms of Salt-Sensitive hypertensionR01HL144941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2025
$3.0M
Proteolytic activation of ENaC in Proteinuric Kidney DiseaseK08DK110332 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RAY, EVAN CROSS · 2016 to 2021
$903k
Training in Renal, GI, Endocrine, and Epithelial BiologyT35DK065521 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEFRANCO, DONALD B, JURCZAK, MICHAEL J. · 2004 to 2024
$811k
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in HypertensionK01HL130497 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2016 to 2020
$803k
Deep phenotypic and functional characterization of salt-responsive immune cells in human salt senstive hypertension using CTE-seqR03HL155041 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2021 to 2022
$173k
NHLBI NIH HHS K01 HL130497NHLBI NIH HHS R01 HL144941NHLBI NIH HHS R01 HL147818NHLBI NIH HHS R03 HL155041NIDDK NIH HHS K08 DK110332NIDDK NIH HHS P30 DK079307NIDDK NIH HHS T32 DK061296NIDDK NIH HHS T35 DK065521
6 · The paper itself

Abstract

The epithelial Na

Indexed as

Blood PressureBlood VolumeDiet, Sodium-RestrictedWater-Electrolyte BalanceAnimalsBiomarkersBody CompositionEpithelial Sodium ChannelsFemaleKidneyLungMaleMiceMice, KnockoutOrganism Hydration StatusSodium Chloride, DietaryBiomarkersEpithelial Sodium ChannelsScnn1g protein, mouseSodium Chloride, Dietaryblood pressuredippingepithelial Na+ channelextracellular fluid volumesodium

Identifiers

PMID34632813
PMCPMC8714976
OpenAlexW3205747788

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.