Evidence map›Paper›PMID 34632802›Full record

ReviewNanomedicine (London, England)2021

Nano-carriers of COVID-19 vaccines: the main pillars of efficacy.

Carolina Constantin, Anissa Pisani, Giuseppe Bardi, Monica Neagu

Open access · greenAbstract readReview
In one paragraph

Review in Nanomedicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Moving Forward in Nano-Immune Interactions.Nanomaterials (Basel, Switzerland) · 2022
    Article
  9. Review
  10. Review
  11. Article
  12. Testing Antigens, Antibodies, and Immune Cells in COVID-19 as a Public Health Topic-Experience and Outlines.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Carolina Constantin"Victor Babeş" National Institute of Pathology, 99-101 Spl Independentei, Bucharest, 050096, Romania.ORCID 0000-0002-2870-5497
Anissa PisaniNanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego 30, Genova, 16163, Italy.ORCID 0000-0003-0691-7349
Giuseppe BardiNanobiointeractions & Nanodiagnostics, Istituto Italiano di Tecnologia, Via Morego 30, Genova, 16163, Italy.ORCID 0000-0001-9662-3007
Monica Neagu"Victor Babeş" National Institute of Pathology, 99-101 Spl Independentei, Bucharest, 050096, Romania.ORCID 0000-0001-9339-2805
Italian Institute of Technology · ITInstitutul National Victor Babes · ROUniversity of Bucharest · RO

Funding

NASR Project PN 19.29.01.01Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.2-PCCDI-2017-341/2018
6 · The paper itself

Abstract

As the current COVID-19 pandemic illustrates, vaccination is the most powerful method of disease prevention and public confidence in vaccines depends on their safety and efficacy. The information gathered in the current pandemic is growing at an accelerated pace. Both the key vital protein DNA/RNA messengers and the delivery carriers are the elements of a puzzle including their interactions with the immune system to suppress SARS-CoV-2 infection. A new nano-era is beginning in the vaccine development field and an array of side applications for diagnostic and antiviral tools will likely emerge. This review focuses on the evolution of vaccine carriers up to COVID-19-aimed nanoparticles and the immune-related adverse effects imposed by these nanocarriers.

Indexed as

COVID-19VaccinesCOVID-19 VaccinesHumansPandemicsSARS-CoV-2COVID-19 VaccinesVaccinesCOVID-19immunitynanoparticlesSARS-CoV-2vaccine carriervaccines

Identifiers

PMID34632802
PMCPMC8544481
OpenAlexW3205145066

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.