ArticleBrain, behavior, & immunity - health2021
Boosting stress resilience using flexibility as a framework to reduce depression risk.
Article in Brain, behavior, & immunity - health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Network structure and mental health correlates of the Mount Sinai Resilience Scale.Journal of psychiatric research · 2026Article
- Reducing state anxiety with alpha-frequency transcranial alternating current stimulation.Research square · 2026Article
- Enhanced Brain-Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- "I'm Ready This Time": Investigating physiological and emotional habituation to repetitive social stress.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2025Article
- The chain mediating effect of psychological inflexibility and stress between physical exercise and adolescent insomnia.Scientific reports · 2024Article
- Editorial commentary on the special issue emerging psychoneuroimmunology research: Future leaders in focus.Brain, behavior, & immunity - health · 2022Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress exposure is inevitable, and major life events often precede depression onset. However, a majority do not develop depression after a major life event. Inflexible physiological responses to stress, in which the magnitude or duration is disproportionate to the stressor, may increase risk for depression - especially in the context of frequent or repetitive stress. Although past psychoneuroimmunology (PNI) research focused primarily on stress response magnitude, two relatively recent stress theories - the Perseverative Cognition Hypothesis and Generalized Unsafety Theory - shift the focus to response duration, including anticipatory reactivity and poor recovery. Using these theories as framework, this article reviews evidence suggesting that psychological inflexibility, such as perseverative cognition, and the inability to recognize safety promote heightened and prolonged (i.e., inflexible) physiological stress responses. Moreover, interventions that increase psychological flexibility or safety recognition may foster more flexible physiological responses to psychological stress. By adopting the lens of flexibility to examine physiological responses to stress, PNI will speak the same language as clinical psychology, which has identified inflexibility as an etiological and maintenance factor of depression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.