Evidence map›Paper›PMID 34632364›Full record

ArticleMaterials today. Bio2021

Bioactive strontium ions/ginsenoside Rg1-incorporated biodegradable silk fibroin-gelatin scaffold promoted challenging osteoporotic bone regeneration.

Tingting Wu, Wenping Liu, Shusen Huang, Jiwen Chen, Fupo He, Huajun Wang, Xiaofei Zheng, Zhenyan Li, Huantian Zhang, Zhengang Zha and 2 more

Open access · goldAbstract read
In one paragraph

Article in Materials today. Bio, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Recent Advances in Silk Fibroin Derived fromJournal of functional biomaterials · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Frontiers in bioengineering and biotechnology · 2023
    Article
  16. Review
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Tingting WuNational Engineering Research Center for Healthcare Devices, Guangdong Key Lab of Medical Electronic Instruments and Polymer Material Products, Institute of Medicine and Health, Guangdong Academy of Sciences, Guangzhou, 510500, China.
Wenping LiuInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Shusen HuangInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Jiwen ChenInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Fupo HeSchool of Electromechanical Engineering, Guangdong University of Technology, Guangzhou, 510006, China.
Huajun WangInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Xiaofei ZhengInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Zhenyan LiInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Huantian ZhangInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Zhengang ZhaInstitute of Orthopedic Diseases, Center for Joint Surgery and Sports Medicine, The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
Zefeng LinGuangdong Key Lab of Orthopedic Technology and Implant, General Hospital of Southern Theater Command of PLA, Guangzhou, 510010, China.
Yuanfeng ChenResearch Center of Medical Science, Department of Orthopedics, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, China.
First Affiliated Hospital of Jinan University · CNGeneral Hospital of Guangzhou Military Command · CNGuangdong Academy of Medical Sciences · CNGuangdong Academy of Sciences · CNGuangdong University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autogenous healing of osteoporotic fractures is challenging, as the regenerative capacity of bone tissues is impaired by estrogen reduction and existed pro-inflammatory cytokines. In this study, a biofunctional ginsenoside Rg1 and strontium-containing mineral (SrHPO

Indexed as

AngiogenesisGinsenoside Rg1Inflammation inhibitionOsteoporotic bone repairStrontium ions

Identifiers

PMID34632364
PMCPMC8488313
OpenAlexW3202830971

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.