Evidence map›Paper›PMID 34632336›Full record

ArticleiScience2021

Zfhx3-mediated genetic ablation of the SCN abolishes light entrainable circadian activity while sparing food anticipatory activity.

Ashleigh G Wilcox, R Sonia Bains, Debbie Williams, Elizabeth Joynson, Lucie Vizor, Peter L Oliver, Elizabeth S Maywood, Michael H Hastings, Gareth Banks, Patrick M Nolan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. A missense mutation in zinc finger homeobox-3 (ZFHX3) impedes growth and alters metabolism and hypothalamic gene expression in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ashleigh G WilcoxMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
R Sonia BainsMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Debbie WilliamsMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Elizabeth JoynsonMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Lucie VizorMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Peter L OliverMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Elizabeth S MaywoodMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Michael H HastingsMRC Laboratory of Molecular Biology, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.
Gareth BanksMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Patrick M NolanMRC Harwell Institute, Harwell Science Campus, Oxfordshire OX11 0RD, UK.
Mary Lyon Centre at MRC Harwell · GBMRC Laboratory of Molecular Biology · GB

Funding

Medical Research Council MC_EX_MR/P502005/1Medical Research Council MC_U105170643Medical Research Council MC_U142684173Medical Research Council MC_UP_1502/1
6 · The paper itself

Abstract

Circadian rhythms persist in almost all organisms and are crucial for maintaining appropriate timing in physiology and behaviour. Here, we describe a mouse mutant where the central mammalian pacemaker, the suprachiasmatic nucleus (SCN), has been genetically ablated by conditional deletion of the transcription factor

Indexed as

Biological sciencesMolecular biologyNeurosciencePhysiology

Identifiers

PMID34632336
PMCPMC8487057
OpenAlexW3200473340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.