Evidence map›Paper›PMID 34632335›Full record

ArticleiScience2021

Restoration of the defect in radial glial fiber migration and cortical plate organization in a brain organoid model of Fukuyama muscular dystrophy.

Mariko Taniguchi-Ikeda, Michiyo Koyanagi-Aoi, Tatsuo Maruyama, Toru Takaori, Akiko Hosoya, Hiroyuki Tezuka, Shotaro Nagase, Takuma Ishihara, Taisuke Kadoshima, Keiko Muguruma and 7 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 12 institutions in 2 countries.

Mariko Taniguchi-IkedaDepartment of Clinical Genetics, Fujita Health University Hospital, 1-98 Dengakugakubo, Kutsukake-chou, Toyoake, Aichi 470-1192, Japan.
Michiyo Koyanagi-AoiDivision of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo 650-0017, Japan.
Tatsuo MaruyamaDepartment of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Hyogo 657-8501, Japan.
Toru TakaoriDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Akiko HosoyaDivision of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo 650-0017, Japan.
Hiroyuki TezukaDepartment of Cellular Function Analysis, Research Promotion and Support Headquarters, Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Shotaro NagaseAsubio Pharma Co., Ltd., Kobe, Hyogo 650-0047, Japan.
Takuma IshiharaInnovative and Clinical Research Promotion Center, Gifu University Hospital, Yanagido, Gifu 501-1194, Japan.
Taisuke KadoshimaAsubio Pharma Co., Ltd., Kobe, Hyogo 650-0047, Japan.
Keiko MugurumaLaboratory for Cell Asymmetry, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan.
Keiko IshigakiDepartment of Pediatrics, Tokyo Women's Medical University, School of Medicine, Shinjuku-ku, Tokyo 162-8666, Japan.
Hidetoshi SakuraiDepartment of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Sakyo-ku, Kyoto 606-8507, Japan.
Akira MizoguchiDepartment of Personalized Cancer Immunotherapy, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
Bennett G NovitchDepartment of Neurobiology, David Geffen School of Medicine at the University of California, Los Angeles (UCLA), Los Angeles, CA 90095, USA.
Tatsushi TodaDepartment of Neurology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Momoko WatanabeDepartment of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, Irvine, CA 92697, USA.
Takashi AoiDivision of Advanced Medical Science, Graduate School of Science, Technology and Innovation, Kobe University, Kobe, Hyogo 650-0017, Japan.
Kobe University Hospital · JPFujita Health University · JPKobe Asahi Hospital · JPKyoto University · JPGifu University Hospital · JPKansai Medical University · JPKobe University · JPMie University · JPThe University of Tokyo · JPTokyo Women's Medical University · JPUniversity of California, Irvine · USUniversity of California, Los Angeles · US

Funding

UCLA IDDRC: Translational CoreP50HD103557 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Michael Gandal · 2020 to 2026
$9.6M
Integrative Modeling of HIV-Associated Neurocognitive Disorder in Human Brain OrganoidsR01DA051897 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FREGOSO, OLIVER I, NOVITCH, BENNETT G · 2020 to 2024
$3.1M
Regulation of neural progenitor functions underlying cortical growth & complexityR01NS089817 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI NOVITCH, BENNETT G · 2015 to 2019
$2.1M
Human cerebral organoids as a model system for neural development and diseaseR00HD096105 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI WATANABE, MOMOKO · 2020 to 2022
$737k
Human cerebral organoids as a model system for neural development and diseaseK99HD096105 · NICHD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATANABE, MOMOKO · 2018 to 2019
$300k
NICHD NIH HHS K99 HD096105NICHD NIH HHS P50 HD103557NICHD NIH HHS R00 HD096105NIDA NIH HHS R01 DA051897NINDS NIH HHS R01 NS089817
6 · The paper itself

Abstract

Fukuyama congenital muscular dystrophy (FCMD) is a severe, intractable genetic disease that affects the skeletal muscle, eyes, and brain and is attributed to a defect in alpha dystroglycan (αDG)

Indexed as

NeurosciencePathophysiologyTissue Engineering

Identifiers

PMID34632335
PMCPMC8487058
OpenAlexW3201151564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.