Evidence map›Paper›PMID 34632318›Full record

ArticleFASEB bioAdvances2021

Sheep models of F508del and G542X cystic fibrosis mutations show cellular responses to human therapeutics.

Iuri Viotti Perisse, Zhiqiang Fan, Arnaud Van Wettere, Ying Liu, Shih-Hsing Leir, Jacob Keim, Misha Regouski, Michael D Wilson, Kelly M Cholewa, Sara N Mansbach and 5 more

Open access · goldAbstract read
In one paragraph

Article in FASEB bioAdvances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Considerations for early life genetic therapies in cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2026
    Review
  5. Article
  6. Article
  7. Cellular imbalance in proximal and distal lung of CFTRMolecular medicine (Cambridge, Mass.) · 2025
    Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Iuri Viotti PerisseDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Zhiqiang FanDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Arnaud Van WettereDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Ying LiuDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Shih-Hsing LeirDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Jacob KeimDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Misha RegouskiDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Michael D WilsonDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Kelly M CholewaDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Sara N MansbachDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Thomas J KelleyDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Zhongde WangDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Ann HarrisDepartment of Genetics and Genome Sciences Case Western Reserve University School of Medicine Cleveland Ohio USA.
Kenneth L WhiteDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Irina A PolejaevaDepartment of Animal, Dairy and Veterinary Sciences Utah State University Logan Utah USA.
Utah State University · USCase Western Reserve University · USUniversity School · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cystic Fibrosis (CF) is a genetic disease caused by mutations in the CF transmembrane conductance regulator (

Indexed as

animal modelsCFTRcloningCRISPR/Cas9human drugs

Identifiers

PMID34632318
PMCPMC8493969
OpenAlexW3179846032

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.