Evidence map›Paper›PMID 34632229›Full record

ArticleACS omega2021

Lipopolysaccharide Is a 4-Aminoarabinose Donor to Exogenous Polyisoprenyl Phosphates through the Reverse Reaction of the Enzyme ArnT.

Beth A Scarbrough, Colleen R Eade, Amanda J Reid, Tiffany C Williams, Jerry M Troutman

Open access · goldAbstract read
In one paragraph

Article in ACS omega, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. The fatty acid synthesis geneMicrobiology spectrum · 2025
    Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Beth A ScarbroughNanoscale Science Program, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
Colleen R EadeDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
Amanda J ReidNanoscale Science Program, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
Tiffany C WilliamsDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.
Jerry M TroutmanDepartment of Chemistry, The University of North Carolina at Charlotte, Charlotte, North Carolina 28223-0001, United States.ORCID https://orcid.org/0000-0002-8340-462X
University of North Carolina at Charlotte · US

Funding

In vitro and Cellular Tools for Complex Polysaccharide BiosynthesisR01GM123251 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI TROUTMAN, JERRY M · 2017 to 2023
$2.1M
Chemoenzymatic preparation of tagged bactoprenyl diphosphate linked sugar probes for in vitro and cellular elucidation of complex bacterial polysaccharidesF31GM130065 · NIGMS · UNIVERSITY OF NORTH CAROLINA CHARLOTTE · PI REID, AMANDA · 2018 to 2020
$101k
NIGMS NIH HHS F31 GM130065NIGMS NIH HHS R01 GM123251
6 · The paper itself

Abstract

Modification of the lipid A portion of LPS with cationic monosaccharides provides resistance to polymyxins, which are often employed as a last resort to treat multidrug-resistant bacterial infections. Here, we describe the use of fluorescent polyisoprenoids, liquid chromatography-mass spectrometry, and bacterial genetics to probe the activity of membrane-localized proteins that utilize the 55-carbon lipid carrier bactoprenyl phosphate (BP). We have discovered that a substantial background reaction occurs when B-strain

Identifiers

PMID34632229
PMCPMC8495848
OpenAlexW3201262516

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.