ArticleBioactive materials2021
PCL and PCL/bioactive glass biomaterials as carriers for biologically active polyphenolic compounds: Comprehensive physicochemical and biological evaluation.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Polyphenol-Enriched Composite Bone Regeneration Materials: A Systematic Review of In Vitro Studies.International journal of molecular sciences · 2022Pooled it
- Engineering polyphenol-based osteogenic system for bone and cartilage repair: Transplantation, tissue engineering, and organoid.Journal of advanced research · 2026Review
- Sol-gel derived silica-based 58S bioactive glass as a carrier forRSC advances · 2026Article
- An "inside-out"-guided genetically engineered hydrogel for augmenting aged bone regeneration.Bioactive materials · 2025Article
- Early Biological Response to Poly(ε-caprolactone) PCL-Bioactive Glass Composites Obtained by 3D Printing as Bone Substitutes.Polymers · 2025Article
- Bacterial-Derived Polyhydroxyalkanoate/Bioceramic Composites in Clinical Practice: State of the Art and Future Perspectives.ACS biomaterials science & engineering · 2025Review
- 3D-Printed Polymeric Biomaterials for Health Applications.Advanced healthcare materials · 2025Review
- A Multidisciplinary Evaluation of Three-Dimensional Polycaprolactone Bioactive Glass Scaffolds for Bone Tissue Engineering Purposes.Materials (Basel, Switzerland) · 2024Article
- Bioactive Glasses Modulate Anticancer Activity and Other Polyphenol-Related Properties of Polyphenol-Loaded PCL/Bioactive Glass Composites.ACS applied materials & interfaces · 2024Article
- Use of Plant Extracts in Polymeric Scaffolds in the Regeneration of Mandibular Injuries.Pharmaceutics · 2024Article
- Polycaprolactone/polyacrylic acid/graphene oxide composite nanofibers as a highly efficient sorbent to remove lead toxic metal from drinking water and apple juice.Scientific reports · 2024Article
- Synergistic anticancer effect of Pistacia lentiscus essential oils and 5-Fluorouracil co-loaded onto biodegradable nanofibers against melanoma and breast cancer.Discover nano · 2024Article
- Enhancing bone tissue engineering with 3D-Printed polycaprolactone scaffolds integrated with tragacanth gum/bioactive glass.Materials today. Bio · 2023Article
- Herbalism and glass-based materials in dentistry: review of the current state of the art.Journal of materials science. Materials in medicine · 2023Review
- Drug-loaded balloon with built-in NIR controlled tip-separable microneedles for long-effective arteriosclerosis treatment.Bioactive materials · 2023Article
- Antibacterial and Cytotoxic Silica-Polycaprolactone-Chlorogenic Acid Hybrids by Sol-Gel Route.Molecules (Basel, Switzerland) · 2023Article
- Antioxidant Effects of Bioactive Glasses (BGs) and Their Significance in Tissue Engineering Strategies.Molecules (Basel, Switzerland) · 2022Review
- Biomaterials and Extracellular Vesicle Delivery: Current Status, Applications and Challenges.Cells · 2022Review
- Recent Advances in the Control of Clinically Important Biofilms.International journal of molecular sciences · 2022Review
- The Changes in Bioactive Compounds and Antioxidant Activity of Chia (Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this work, polymeric and bioactive glass (BG)-modified composite films were successfully loaded with polyphenols (PPh) extracted from sage. It was hypothesized that PPh, alone and in combination with BGs particles, would affect physicochemical and biological properties of the films. Furthermore, sol-gel-derived BG particles would serve as an agent for control the release of the polyphenolic compounds, and other important properties related to the presence of PPh. The results showed that polyphenolic compounds significantly modified numerous material properties and also acted as biologically active substances. On the one hand, PPh can be considered as plasticizers for PCL, on the other hand, they can act as coupling agent in composite materials, improving their mechanical performance. The presence of PPh in materials improved their hydrophilicity and apatite-forming ability, and also provided antioxidant activity. What is important is that the aforementioned properties and kinetics of PPh release can be modulated by the use of various concentrations of PPh, and by the modification of PCL matrix with sol-gel-derived BG particles, capable of binding PPh. The films containing the lowest concentration of PPh exhibited cytocompatibility, significantly increased alkaline phosphatase activity and the expression of bone extracellular matrix proteins (osteocalcin and osteopontin) in human normal osteoblasts, while they reduced intracellular reactive oxygen species production in macrophages. Furthermore, materials loaded with PPh showed antibiofilm properties against Gram positive and Gram negative bacteria. The results suggest that obtained materials represent potential multifunctional biomaterials for bone tissue engineering with a wide range of tunable properties.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.