Evidence map›Paper›PMID 34632135›Full record

ReviewHeliyon2021

Lipid nanostructures for targeting brain cancer.

Hamdi Nsairat, Dima Khater, Fadwa Odeh, Fedaa Al-Adaileh, Suma Al-Taher, Areej M Jaber, Walhan Alshaer, Abeer Al Bawab, Mohammad S Mubarak

Abstract readReview
In one paragraph

Review in Heliyon, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
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  13. Nanomedicine (London, England) · 2024
    Article
  14. Review
  15. Nano-inspired smart medicines targeting brain cancer: diagnosis and treatment.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2023
    Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hamdi NsairatPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Dima KhaterDepartment of Chemistry, Faculty of Arts and Science, Applied Science Private University, Amman 11931, Jordan.
Fadwa OdehDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.
Fedaa Al-AdailehDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.
Suma Al-TaherDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.
Areej M JaberPharmacological and Diagnostic Research Center, Faculty of Pharmacy, Al-Ahliyya Amman University, Amman 19328, Jordan.
Walhan AlshaerCell Therapy Center, The University of Jordan, Amman 11942, Jordan.
Abeer Al BawabDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.
Mohammad S MubarakDepartment of Chemistry, The University of Jordan, Amman 11942, Jordan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Advancements in both material science and bionanotechnology are transforming the health care sector. To this end, nanoparticles are increasingly used to improve diagnosis, monitoring, and therapy. Huge research is being carried out to improve the design, efficiency, and performance of these nanoparticles. Nanoparticles are also considered as a major area of research and development to meet the essential requirements for use in nanomedicine where safety, compatibility, biodegradability, biodistribution, stability, and effectiveness are requirements towards the desired application. In this regard, lipids have been used in pharmaceuticals and medical formulations for a long time. The present work focuses on the use of lipid nanostructures to combat brain tumors. In addition, this review summarizes the literature pertaining to solid lipid nanoparticles (SLN) and nanostructured lipid carriers (LNC), methods of preparation and characterization, developments achieved to overcome blood brain barrier (BBB), and modifications used to increase their effectiveness.

Indexed as

Blood brain barrier (BBB)GlioblastomaLipid nanocarriers (LNC)Lipid nanoparticlesSolid lipid nanoparticles (SLN)

Identifiers

PMID34632135
PMCPMC8488847

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.