SynthesisBMJ open ophthalmology2021
Role of hypertension as a risk factor for open-angle glaucoma: a systematic review and meta-analysis.
Synthesis in BMJ open ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Ocular and Systemic Risk Factors and Biomarkers for Primary Glaucoma: An Umbrella Review of Systematic Reviews With Meta-Analyses.Investigative ophthalmology & visual science · 2025Pooled it
- The Relevance of Arterial Blood Pressure in the Management of Glaucoma Progression: A Systematic Review.American journal of hypertension · 2024Pooled it
- Beyond intraocular pressure: vascular and metabolic modifiers of optic nerve vulnerability in glaucoma.International ophthalmology · 2026Review
- Observational
- Real-World Performance and Safety of VISIOL in Modern Routine Cataract Surgery.Ophthalmology and therapy · 2026Article
- Diabetes Burden and Healthcare Barriers Among Cataract Patients in Imo State, Nigeria.Annals of global health · 2026Article
- A Blurred Vision of Health: Metabolic Syndrome as a Risk Factor for Glaucoma in a Large Taiwanese Population Study.International journal of medical sciences · 2026Article
- Risk of Glaucoma after Pars Plana Vitrectomy in a Large Federated Health Record Network.Ophthalmology science · 2026Article
- The relationship between aldosterone-induced retinal ganglion cell loss, blood pressure, and intraocular pressure.Japanese journal of ophthalmology · 2025Article
- Association between life's essential 8 cardiovascular health score and glaucoma risk: evidence from NHANES.International ophthalmology · 2025Article
- Risk of depression in glaucoma patients with vision impairment: A nationwide cohort study.Heliyon · 2025Article
- Development of a novel scoring system for glaucoma risk based on demographic and laboratory factors using ChatGPT-4.Medical & biological engineering & computing · 2025Article
- Role of reactive oxygen species and oxidative stress in the pathomechanism of glaucoma.Medical hypothesis, discovery & innovation ophthalmology journal · 2025Review
- Color Doppler Imaging Assessment of Ocular Blood Flow Following Ab Externo Canaloplasty in Primary Open-Angle Glaucoma.Journal of clinical medicine · 2024Article
- Article
- Inflammation and Neurodegeneration in Glaucoma: Isolated Eye Disease or a Part of a Systemic Disorder? - Serum Proteomic Analysis.Journal of inflammation research · 2024Article
- Association of trabecular meshwork height with steroid-induced ocular hypertension.Scientific reports · 2023Article
- Appraising the Effects of Metabolic Traits on the Risk of Glaucoma: A Mendelian Randomization Study.Metabolites · 2023Article
- Association of Ambulatory Blood Pressure and Other Factors With Intraocular Pressure-Related 24-Hour Contact Lens Sensor Profile in Untreated Glaucoma.Translational vision science & technology · 2022Article
- Matrix Metalloproteinases and Glaucoma.Biomolecules · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Glaucoma is the leading cause of irreversible blindness. It is estimated that as many as 3.2 million people worldwide experience blindness due to glaucoma, including open-angle glaucoma (OAG). Until now, there is no definite mechanism related to the incidence of OAG. However, increased intraocular pressure (IOP) is considered to be the most important risk factor. Several current studies show that there is a significant relationship between hypertension (HTN) and IOP. In particular, several epidemiological studies have shown that an increase in systemic blood pressure (BP) is associated with an increase in IOP. However, several studies report that high BP provides a protective effect at a young age against the incidence of OAG. Therefore, this literature aims to explore the effect of HTN on the incidence of OAG. In this review, search for the literature using keywords that match the topic, then a gradual screening was carried out with the predetermined eligibility criteria. From 3711 studies, 16 studies matched the criteria having a total sample size of 72 212 and then a quantitative meta-analysis was conducted. The results showed a risk ratio of 1.69 (95% CI 1.50 to 1.90) in the HTN group. However, from our qualitative synthesis, we found that people who have an unstable diastolic blood pressure (DBP), either high or low, are both able to increase the risk of OAG events. In conclusion, we found that HTN was able to increase the risk of OAG and DBP instability, whether high or low, can also increase the risk of OAG incidence.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.