Evidence map›Paper›PMID 34632048›Full record

ArticleAdvanced therapeutics2021

Optimization of microbubble-based DNA vaccination with low-frequency ultrasound for enhanced cancer immunotherapy.

Nisi Zhang, Josquin Foiret, Azadeh Kheirolomoom, Pei Liu, Yi Feng, Spencer Tumbale, Marina Raie, Bo Wu, James Wang, Brett Z Fite and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Nisi ZhangDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Josquin FoiretDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Azadeh KheirolomoomDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Pei LiuDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Yi FengDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Spencer TumbaleDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Marina RaieDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Bo WuDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
James WangDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Brett Z FiteDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Zhifei DaiDepartment of Engineering, Peking University, Beijing, China.
Katherine W FerraraDepartment of Radiology, Stanford University, Palo Alto, CA, USA.
Palo Alto University · USPeking University · CN

Funding

Specific and high-resolution ultrasound cancer imagingR01CA112356 · NCI · UNIVERSITY OF CALIFORNIA DAVIS · PI FERRARA, KATHERINE W, FOIRET, JOSQUIN · 2005 to 2022
$6.1M
Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
In vivo PET imaging of novel engineered AAVs informs capsid design in Alzheimer's DiseaseR01EB028646 · NIBIB · STANFORD UNIVERSITY · PI FERRARA, KATHERINE W · 2019 to 2022
$3.8M
Imaging Modulation of Immune PhenotypeR01CA250557 · NCI · STANFORD UNIVERSITY · PI FERRARA, KATHERINE W, LEVY, RONALD · 2021 to 2025
$3.2M
The Impact of FUS-Mediated Brain Cancer Therapy on BBB Transport, Cytokines, and Immunocyte TraffickingR01CA227687 · NCI · STANFORD UNIVERSITY · PI BUTTS-PAULY, KIM · 2018 to 2022
$3.1M
3D Passive Cavitation Imaging-Guided Therapeutic Delivery of MicroRNA into CancerR21EB022298 · NIBIB · STANFORD UNIVERSITY · PI PAULMURUGAN, RAMASAMY · 2016 to 2017
$441k
Celigo S Imaging Cytometer (200-BFFL-S)S10OD023518 · OD · STANFORD UNIVERSITY · PI PAULMURUGAN, RAMASAMY · 2018 to 2018
$174k
NCI NIH HHS R01 CA112356NCI NIH HHS R01 CA227687NCI NIH HHS R01 CA250557NCI NIH HHS T32 CA118681NIBIB NIH HHS R01 EB028646NIBIB NIH HHS R21 EB022298NIH HHS S10 OD023518
6 · The paper itself

Abstract

Immunotherapy is an important cancer treatment strategy; nevertheless, the lack of robust immune cell infiltration in the tumor microenvironment remains a factor in limiting patient response rates.

Indexed as

CancerGene transfectionImmunotherapyMicrobubbleUltrasound

Identifiers

PMID34632048
PMCPMC8494128
OpenAlexW3169764416

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.