Evidence map›Paper›PMID 34631946›Full record

ArticleMovement disorders clinical practice2021

Sudden Onset, Fixed Dystonia and Acute Peripheral Trauma as Diagnostic Clues for Functional Dystonia.

Tommaso Ercoli, Giovanni Defazio, Christian Geroin, Enrico Marcuzzo, Giovanni Fabbrini, Francesco Bono, Alessandro Mechelli, Roberto Ceravolo, Luigi Michele Romito, Alberto Albanese and 11 more

Open access · hybridAbstract read
In one paragraph

Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Polyelectromyography Under Propofol to Differentiate Functional from Idiopathic Dystonia: A Pilot Study.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  4. The Second Hit Hypothesis in Animal and Human Dystonia: The Role of Peripheral Nerve Trauma and Spinal Cord Injury.Movement disorders : official journal of the Movement Disorder Society · 2026
    Review
  5. Article
  6. Definition and Classification of Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2025
    Review
  7. Article
  8. Genetic Update and Treatment for Dystonia.International journal of molecular sciences · 2024
    Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 13 institutions in 1 country.

Tommaso ErcoliDepartment of Medical Sciences and Public Health University of Cagliari Cagliari Italy.
Giovanni DefazioDepartment of Medical Sciences and Public Health University of Cagliari Cagliari Italy.
Christian GeroinNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy.ORCID https://orcid.org/0000-0001-6095-1930
Enrico MarcuzzoNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy.
Giovanni FabbriniDepartment of Human Neurosciences Sapienza University of Rome Rome Italy.
Francesco BonoBotulinum Toxin Center, Neurology Unit A.O.U. Mater Domini Catanzaro Italy.
Alessandro MechelliBotulinum Toxin Center, Neurology Unit A.O.U. Mater Domini Catanzaro Italy.
Roberto CeravoloNeurology Unit, Department of Clinical and Experimental Medicine University of Pisa Pisa Italy.ORCID https://orcid.org/0000-0003-1412-9406
Luigi Michele RomitoParkinson and Movement Disorders Unit Fondazione IRCCS Istituto Neurologico Carlo Besta Milan Italy.ORCID https://orcid.org/0000-0002-6772-1035
Alberto AlbaneseDepartment of Neurology IRCCS Humanitas Research Hospital Rozzano Italy.ORCID https://orcid.org/0000-0002-5864-0006
Antonio PisaniDepartment of Brain and Behavioral Sciences University of Pavia Pavia Italy.ORCID https://orcid.org/0000-0002-8432-594X
Maurizio ZibettiDepartment of Neuroscience-Rita Levi Montalcini University of Turin Turin Italy.
Maria Concetta AltavistaUOC di Neurologia Ospedale San Filippo Neri Rome Italy.
Luca MadernaDepartment of Neurology-Stroke Unit and Laboratory of Neurosciences Istituto Auxologico Italiano, IRCCS Milan Italy.
Martina PetraccaFondazione Policlinico Universitario 'Agostino Gemelli'-IRCCS Rome Italy.ORCID https://orcid.org/0000-0001-8033-3785
Paolo GirlandaDepartment of Clinical and Experimental Medicine University of Messina Messina Italy.
Marcello Mario MasciaDepartment of Medical Sciences and Public Health University of Cagliari Cagliari Italy.ORCID https://orcid.org/0000-0002-9028-5972
Alfredo BerardelliDepartment of Human Neurosciences Sapienza University of Rome Rome Italy.ORCID https://orcid.org/0000-0003-3598-3142
Michele TinazziNeurology Unit, Movement Disorders Division, Department of Neurosciences, Biomedicine and Movement Sciences University of Verona Verona Italy.
Italian Registry of Functional Motor Disorders Study Group
Italian Registry of Adult Dystonia Study Group
University of Cagliari · ITUniversity of Verona · ITAzienda Ospedaliero Universitario Mater Domini · ITIstituto Neurologico Mediterraneo · ITAgostino Gemelli University Polyclinic · ITFondazione IRCCS Istituto Neurologico Carlo Besta · ITIRCCS Humanitas Research Hospital · ITIRCCS Istituto Auxologico Italiano · ITOspedale San Filippo Neri · ITUniversity of Messina · ITUniversity of Pavia · ITUniversity of Pisa · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe differentiation of functional dystonia from idiopathic dystonia may be clinically challenging.

objectiveTo identify clinical features suggestive of functional dystonia to guide physicians to distinguish functional dystonia from idiopathic dystonia.

methodsPatient data were extracted from the Italian Registry of Functional Motor Disorders and the Italian Registry of Adult Dystonia. Patients with functional and idiopathic dystonia were followed up at the same clinical sites, and they were similar in age and sex.

resultsWe identified 113 patients with functional dystonia and 125 with idiopathic dystonia. Sudden onset of dystonia, evidence of fixed dystonia, and acute peripheral trauma before dystonia onset were more frequent in the functional dystonia group. No study variable alone achieved satisfactory sensitivity and specificity, whereas a combination of variables yielded 85% sensitivity and 98% specificity. A diagnostic algorithm was developed to reduce the risk of misclassifying functional dystonia.

conclusionOur findings extend the current diagnostic approach to functional dystonia by showing that clinical information about symptom onset, fixed dystonia, and history of peripheral trauma may provide key clues in the diagnosis of functional dystonia.

Indexed as

acute peripheral traumafixed dystoniafunctional dystoniaidiopathic dystoniasudden onset

Identifiers

PMID34631946
PMCPMC8485608
OpenAlexW3198790571

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.