ArticleMovement disorders clinical practice2021
Dream Content Predicts Motor and Cognitive Decline in Parkinson's Disease.
Article in Movement disorders clinical practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Posttraumatic Stress Disorder and Handgrip Strength Among World Trade Center Firefighters and Emergency Medical Responders.International journal of environmental research and public health · 2026Article
- Parasomnias in movement disorders: a narrative review.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Neuroimaging-based data-driven subtypes of spatiotemporal atrophy due to Parkinson's disease.Brain communications · 2025Article
- Prodromal dreams.Frontiers in psychiatry · 2025Article
- To be or not to be hallucinating: Implications of hypnagogic/hypnopompic experiences and lucid dreaming for brain disorders.PNAS nexus · 2024Article
- Distressing dreams, cognitive decline, and risk of dementia: A prospective study of three population-based cohorts.EClinicalMedicine · 2022Article
- Distressing dreams and risk of Parkinson's disease: A population-based cohort study.EClinicalMedicine · 2022Article
- Correlation of Antidepressant Use and Symptom Time Period in Dream Enactment Behaviors.Movement disorders clinical practice · 2022Article
- Reply to: Correlation of Antidepressant Use and Symptom Time Period in Dream Enactment Behaviors.Movement disorders clinical practice · 2022Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDream content alterations in Parkinson's disease (PD) are associated with motor and cognitive dysfunction cross-sectionally. Although recent studies suggest abnormal dream content in PD might also predict cognitive decline, the relationship between dream content and motor decline in PD remains unknown.
objectiveTo investigate whether abnormal dream content in PD predicts both motor and cognitive decline.
methodsData were obtained from the Parkinson's Progression Markers Initiative cohort study. Patients were evaluated at baseline and at the 60-month follow-up, with validated clinical scales, including the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), Montreal Cognitive Assessment (MoCA), and the Movement Disorder Society-Unified Parkinson's Disease Rating Scale Part III (MDS-UPDRS III). Patients were dichotomized using RBDSQ item 2, which inquires whether they frequently experience aggression in their dreams. Regression analyses were used to assess whether frequent aggressive dreams at baseline predicted longitudinal changes in MDS-UPDRS III and MoCA scores as well as progression to Hoehn and Yahr stage 3 (H&Y ≥ 3) and cognitive impairment.
resultsOf the patients, 58/224 (25.9%) reported frequent aggressive dreams at baseline. Aggressive dreams predicted a faster increase in MDS-UPDRS III scores (β = 4.64;
conclusionsThis study demonstrates for the first time that frequent aggressive dreams in newly diagnosed PD may independently predict early motor and cognitive decline.
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