Evidence map›Paper›PMID 34631897›Full record

ArticleJournal of immunology research2021

Increased Circulating CD4

Na Xiao, Xin He, Haiyue Niu, Hong Yu, Ningbo Cui, Hongzhao Li, Li Yan, Zonghong Shao, Limin Xing, Huaquan Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Na XiaoDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Xin HeDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Haiyue NiuDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Hong YuDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Ningbo CuiDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Hongzhao LiDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Li YanDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Zonghong ShaoDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.
Limin XingDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0002-0182-8892
Huaquan WangDepartment of Hematology, General Hospital, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0003-2402-2717
Tianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesImmune abnormalities play an important role in the pathogenesis and progression of myelodysplastic syndrome (MDS). Some patients with MDS have autoimmune diseases (AI). Follicular helper T (Tfh) cells help B cells produce antibodies. The role of Tfh in MDS with AI has not been studied.

methodsWe enrolled 21 patients with MDS with AI and 21 patients with MDS without AI. The proportion of peripheral blood CD4

resultsMDS with AI accounted for 19.6% of all MDS cases in our study. The overall response rate was 81% (17/21) in MDS patients with AI for the first-line treatment. The proportion of circulating CD4

conclusionCD4

Indexed as

AdultAgedAged, 80 and overAutoimmune DiseasesB-LymphocytesFemaleFlow CytometryGlucocorticoidsHumansImmunoglobulin GLymphocyte CountMaleMiddle AgedMyelodysplastic SyndromesProgrammed Cell Death 1 ReceptorReceptors, CXCR5GlucocorticoidsImmunoglobulin GPDCD1 protein, humanProgrammed Cell Death 1 ReceptorReceptors, CXCR5

Identifiers

PMID34631897
PMCPMC8497158
OpenAlexW3204564629

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.