ArticleFrontiers in medicine2021
Case Report: Diagnostic Value of Metagenomics Next Generation Sequencing in Intracranial Infection Caused by Mucor.
Article in Frontiers in medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Plasma metagenomic cfDNA sequencing identifies pathogens in culture-negative sepsis following urinary pouch rupture.BMJ case reports · 2026Article
- Metagenomic next-generation sequencing: new horizons in microbiology.Frontiers in cellular and infection microbiology · 2026Review
- Malassezia restricta as an unexpected cause of infectious osteomyelitis diagnosed by metagenomic sequencing: a case report and literature review.BMC infectious diseases · 2024Review
- Case report: special imaging features in a uremic patient with intracranial infection caused byFrontiers in medicine · 2024Article
- Article
- Diagnostic value of metagenomic next-generation sequencing in sepsis and bloodstream infection.Frontiers in cellular and infection microbiology · 2023Article
- Case report: The clinical utility of metagenomic next-generation sequencing in mucormycosis diagnosis caused by fatalFrontiers in pediatrics · 2023Article
- Invasive splenic mucormycosis due toFrontiers in oncology · 2023Article
- The application of metagenomic next-generation sequencing in patients with infection or colonization caused byFrontiers in cellular and infection microbiology · 2023Article
- Early detection of gram-negative bacteria using metagenomic next-generation sequencing in acute respiratory distress syndrome: A case report.Experimental and therapeutic medicine · 2022Article
- Nasal and cutaneous mucormycosis in two patients with lymphoma after chemotherapy and target therapy: Early detection by metagenomic next-generation sequencing.Frontiers in cellular and infection microbiology · 2022Article
- Detection of Japanese Encephalitis by Metagenomic Next-Generation Sequencing of Cerebrospinal Fluid: A Case Report and Literature Review.Frontiers in cellular neuroscience · 2022Article
- Clinical value of metagenomic next-generation sequencing by Illumina and Nanopore for the detection of pathogens in bronchoalveolar lavage fluid in suspected community-acquired pneumonia patients.Frontiers in cellular and infection microbiology · 2022Article
- The diagnostic value of metagenomic next-generation sequencing for identifyingFrontiers in cellular and infection microbiology · 2022Article
- Metagenomic Next-Generation Sequencing for Diagnostically Challenging Mucormycosis in Patients with Hematological Malignancies.Infection and drug resistance · 2022Article
- Case report: A rare case of pulmonary mucormycosis caused byFrontiers in oncology · 2022Article
- Case Report: Metagenomics Next-Generation Sequencing for Diagnosing Cerebral Infarction and Infection Caused by Hematogenous Disseminated Mucormycosis in a Patient With Acute Lymphoblastic Leukemia.Frontiers in medicine · 2021Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
mNGS(metagenomics Next Generation Sequencing), as a novel culture-independent approach, demonstrated the capability of rapid, sensitive, and accurate pathogen identification. At present, there have been many case reports about the use of mNGS to assist in the diagnosis of bacterial, fungal, viral and parasitic infections and to guide clinicians to determine appropriate treatment. However, the clinical understanding of this technique is not comprehensive, and the experience of using it is relatively limited. We reported a 53-year-old man who was admitted to hospital with a high fever and headache. His inflammatory biomarkers were markedly elevated. Based on the clinical presentation, He was initially diagnosed as having an intracranial infection of unknown etiology and received empirical antibiotics and systemic supportive treatment. But these did not relieve his symptoms. Both the blood and CSF specimens were examined using traditional culture, serological testing, and mNGS. Traditional culture and serological testing produced negative results, while the mNGS revealed the presence of a potential pathogen,
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