Evidence map›Paper›PMID 34631713›Full record

ArticleFrontiers in cell and developmental biology2021

Characterization of Molecular Heterogeneity Associated With Tumor Microenvironment in Clear Cell Renal Cell Carcinoma to Aid Immunotherapy.

Weimin Zhong, Yinan Li, Yichu Yuan, Hongbin Zhong, Chaoqun Huang, Jiwei Huang, Yao Lin, Jiyi Huang

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
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  3. Review
  4. Exploring the role of CD8FEBS open bio · 2024
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  12. ImmunoPET Imaging with 89Zr-Labeled Atezolizumab Enables In Vivo Evaluation of PD-L1 in Tumorgraft Models of Renal Cell Carcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Weimin ZhongThe Fifth Hospital of Xiamen, Xiamen, China.
Yinan LiDepartment of Nephrology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yichu YuanDepartment of Urology, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
Hongbin ZhongThe Fifth Hospital of Xiamen, Xiamen, China.
Chaoqun HuangThe Fifth Hospital of Xiamen, Xiamen, China.
Jiwei HuangDepartment of Urology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yao LinCentral Laboratory at the Second Affiliated Hospital of Fujian Traditional Chinese Medical University, Collaborative Innovation Center for Rehabilitation Technology, Fujian University of Traditional Chinese Medicine, Fuzhou, China.
Jiyi HuangThe Fifth Hospital of Xiamen, Xiamen, China.
Fifth Hospital of Shijiazhuang · CNFujian Medical University · CNFujian University of Traditional Chinese Medicine · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common type of kidney cancer and has strong immunogenicity. A systematically investigation of the tumor microenvironment (TME) in ccRCC could contribute to help clinicians develop personalized treatment and facilitate clinical decision-making. In this study, we analyzed the immune-related subtype of ccRCC on the basis of immune-related gene expression data in The Cancer Genome Atlas (TCGA,

Indexed as

chemo drugsclear cell renal cell carcinomaimmune checkpoint blockadeimmunotherapyIR scoremolecular subtypetumor microenvironment

Identifiers

PMID34631713
PMCPMC8495029
OpenAlexW3202400684

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.