Evidence map›Paper›PMID 34631600›Full record

ArticleFrontiers in cellular and infection microbiology2021

Cysteamine Inhibits Glycine Utilisation and Disrupts Virulence in

Douglas J Fraser-Pitt, Stephen K Dolan, David Toledo-Aparicio, Jessica G Hunt, Daniel W Smith, Niamh Lacy-Roberts, Piumi Sara Nupe Hewage, Teodora N Stoyanova, Erin Manson, Kevin McClean and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Distinctive Lacritin Cleavage-Potentiated Bactericidal Alteration of thebioRxiv : the preprint server for biology · 2026
    Article
  2. Review
  3. Article
  4. ENcyclopedia of TRAnscription Factors in Bacteria and Archaea genomes (ENTRAF) version 2.0.Database : the journal of biological databases and curation · 2025
    Article
  5. Adaptive response ofMicrobiology (Reading, England) · 2024
    Article
  6. Article
  7. Pseudomonas aeruginosa in the Cystic Fibrosis Lung.Advances in experimental medicine and biology · 2022
    Article
  8. Virulence Factors ofFrontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 2 countries.

Douglas J Fraser-PittNovaBiotics Ltd, Aberdeen, United Kingdom.
Stephen K DolanDepartment of Biochemistry, University of Cambridge, Cambridge, United Kingdom.
David Toledo-AparicioNovaBiotics Ltd, Aberdeen, United Kingdom.
Jessica G HuntNovaBiotics Ltd, Aberdeen, United Kingdom.
Daniel W SmithNovaBiotics Ltd, Aberdeen, United Kingdom.
Niamh Lacy-RobertsSNIPR Biome, University of Copenhagen, Copenhagen, Denmark.
Piumi Sara Nupe HewageSchool of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, United Kingdom.
Teodora N StoyanovaSchool of Pharmacy and Life Sciences, Robert Gordon University, Aberdeen, United Kingdom.
Erin MansonCollege of Medical, Veterinary & Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Kevin McCleanProteomics Facility Services, Moredun Research Institute, Penicuik, United Kingdom.
Neil F InglisProteomics Facility Services, Moredun Research Institute, Penicuik, United Kingdom.
Derry K MercerNovaBiotics Ltd, Aberdeen, United Kingdom.
Deborah A O'NeilNovaBiotics Ltd, Aberdeen, United Kingdom.
NovaBiotics (United Kingdom) · GBMoredun Research Institute · GBRobert Gordon University · GBUniversity of Cambridge · GBUniversity of Copenhagen · DKUniversity of Glasgow · GB

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Pseudomonas aeruginosaPseudomonas InfectionsBiofilmsCysteamineGlycineHumansVirulenceCysteamineGlycinebiofilmglycine cleavage complexnovel therapeuticPseudomonas aeruginosavirulence

Identifiers

PMID34631600
PMCPMC8494450
OpenAlexW3200707243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.