Evidence map›Paper›PMID 34631581›Full record

ReviewFrontiers in oncology2021

Exosomes: A New Pathway for Cancer Drug Resistance.

Yunbin Zhong, Haibo Li, Peiwen Li, Yong Chen, Mengyao Zhang, Zhendong Yuan, Yufang Zhang, Zhijie Xu, Geng Luo, Yuan Fang and 1 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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  7. Tumor-derived extracellular vesicles: Bridging communication and next-generation theranostics.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Review
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  14. The theragnostic advances of exosomes in managing leukaemia.Journal of cellular and molecular medicine · 2024
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Frontiers in immunology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 1 country.

Yunbin ZhongHand, Foot Vascular Surgery, Tungwah Hospital to Sun Yet-sen University, Dongguan, China.
Haibo LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Peiwen LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Yong ChenDermatology Department, The First Hospital of Changsha, Changsha, China.
Mengyao ZhangDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Zhendong YuanHand, Foot Vascular Surgery, Tungwah Hospital to Sun Yet-sen University, Dongguan, China.
Yufang ZhangAnyang Tumor Hospital, The Fourth Affiliated Hospital of Henan University of Science and Technology, Anyang, China.
Zhijie XuDepartment of Pathology, Xiangya Hospital, Central South University, Changsha, China.
Geng LuoHand, Foot Vascular Surgery, Tungwah Hospital to Sun Yet-sen University, Dongguan, China.
Yuan FangDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Xu LiDepartment of Plastic Surgery, The Third Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNTung Wah Hospital · CNAnyang Tumor Hospital · CNShanghai Ninth People's Hospital · CNThe First Hospital of Changsha · CNThird Xiangya Hospital · CNXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are extracellular vesicles (EVs) that are secreted into body fluids by multiple cell types and are enriched in bioactive molecules, although their exact contents depend on the cells of origin. Studies have shown that exosomes in the tumor microenvironment affect tumor growth, metastasis and drug resistance by mediating intercellular communication and the transport of specific molecules, although their exact mechanisms of action need to be investigated further. In this review, we have summarized current knowledge on the relationship between tumor drug resistance and exosomes, and have discussed the potential applications of exosomes as diagnostic biomarkers and therapeutic targets.

Indexed as

cancerchemoresistancedrug resistanceexosomessignal transmissiontumor microenvironment

Identifiers

PMID34631581
PMCPMC8497983
OpenAlexW3202055940

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.