ArticleFrontiers in oncology2021
Prediction Model for Lung Cancer in High-Risk Nodules Being Considered for Resection: Development and Validation in a Chinese Population.
Article in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Radiomics based on enhanced CT for differentiating between pulmonary tuberculosis and pulmonary adenocarcinoma presenting as solid nodules or masses.Journal of cancer research and clinical oncology · 2023Trial
- Artificial Intelligence in Lung Cancer: A Narrative Review of Recent Advances in Diagnosis, Biomarker Discovery, and Drug Development.Pharmaceutics · 2026Review
- Predictive Factors and Nomogram for Malignant Pulmonary Nodules (≤ 1 cm).Canadian respiratory journal · 2026Article
- Predictive model of malignancy probability in pulmonary nodules based on multicenter data.Frontiers in oncology · 2025Article
- Computed tomography characteristics of cN0 primary non-small cell lung cancer predict occult lymph node metastasis.European radiology · 2024Article
- Construction of a risk prediction model for isolated pulmonary nodules 5-15 mm in diameter.Translational lung cancer research · 2024Article
- Article
- Nomogram combining clinical and radiological characteristics for predicting the malignant probability of solitary pulmonary nodules measuring ≤ 2 cm.Frontiers in oncology · 2023Article
- Editorial: Surgical Selection of Sublobar Resection and Scope of Lymph Node Dissection for Early-Stage Lung Cancer.Frontiers in surgery · 2022Article
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11 authors.
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Abstract
backgroundDetermining benign and malignant nodules before surgery is very difficult when managing patients with pulmonary nodules, which further makes it difficult to choose an appropriate treatment. This study aimed to develop a lung cancer risk prediction model for predicting the nature of the nodule in patients' lungs and deciding whether to perform a surgical intervention.
methodsThis retrospective study included patients with pulmonary nodules who underwent lobectomy or sublobectomy at Tianjin Medical University General Hospital between 2017 and 2020. All subjects were further divided into training and validation sets. Multivariable logistic regression models with backward selection based on the Akaike information criterion were used to identify independent predictors and develop prediction models.
resultsTo build and validate the model, 503 and 260 malignant and benign nodules were used. Covariates predicting lung cancer in the current model included female sex, age, smoking history, nodule type (pure ground-glass and part-solid), nodule diameter, lobulation, margin (smooth, or spiculated), calcification, intranodular vascularity, pleural indentation, and carcinoembryonic antigen. The final model of this study showed excellent discrimination and calibration with a concordance index (C-index) of 0.914 (0.890-0.939). In an independent sample used for validation, the C-index for the current model was 0.876 (0.825-0.927) compared with 0.644 (0.559-0.728) and 0.681 (0.605-0.757) for the Mayo and Brock models. The decision curve analysis showed that the current model had higher discriminatory power for malignancy than the Mayo and the Brock models.
conclusionsThe current model can be used in estimating the probability of lung cancer in nodules requiring surgical intervention. It may reduce unnecessary procedures for benign nodules and prompt diagnosis and treatment of malignant nodules.
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