ReviewWorld journal of nephrology2021
Serum phosphate and chronic kidney and cardiovascular disease: Phosphorus potential implications in general population.
Review in World journal of nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Pigskin Collagen-Derived Antifreeze Peptides as Clean-Label Cryoprotectants: Inhibition of Ice Recrystallization and Suppression of Oxidative Deterioration in Heme-Rich Pork Sausages.Foods (Basel, Switzerland) · 2026Article
- Comparison of AI-generated renal diets by different large language models: a guideline-based evaluation with expert input.BMC nephrology · 2026Article
- Prognostic Analysis of ICU Patients with Chronic Obstructive Pulmonary Disease Based on Blood Phosphate Dynamics: A Retrospective Cohort Study from the MIMIC-IV Database.International journal of chronic obstructive pulmonary disease · 2026Article
- Article
- Effect of changes trajectory of serum phosphate levels on the 28-day mortality risk in patients with sepsis: a retrospective cohort study from the MIMIC-IV database.BMC infectious diseases · 2025Article
- Study of plasma essential element concentrations to explore markers of acute myocardial infarction.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Targeting serum phosphate trajectory stratification to improve outcomes in high-risk Cardiovascular-Kidney-Metabolic-Sepsis cohorts.PloS one · 2025Article
- Chronic Kidney Disease-associated Lung Injury Is Mediated by Phosphate-induced MAPK/AKT Signaling.American journal of respiratory cell and molecular biology · 2024Article
- Association of serum phosphate and changes in serum phosphate with 28-day mortality in septic shock from MIMIC-IV database.Scientific reports · 2023Article
- Breast Cancer and Bone Mineral Density in a U.S. Cohort of Middle-Aged Women: Associations with Phosphate Toxicity.Cancers · 2023Article
- Industrial Use of Phosphate Food Additives: A Mechanism Linking Ultra-Processed Food Intake to Cardiorenal Disease Risk?Nutrients · 2023Review
- NADCells · 2022Review
- A non-linear positive relationship between serum phosphate and clinical outcomes in sepsis.Heliyon · 2022Article
- Comparative assessment of blood mercury in American alligators (Alligator mississippiensis) from Coastal North Carolina and Florida.Ecotoxicology (London, England) · 2022Article
- Biomarkers and Predictors of Adverse Cardiovascular Events in Different Stages of Chronic Kidney Disease.Dose-response : a publication of International Hormesis SocietyReview
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It has already been established that in end-stage renal disease, hyperphosphatemia causes soft tissue calcification including vascular calcifications. It has also been supported that there is a connection between increased serum phosphate and morbidity in subjects, who suffer from renal disease. However, studies in these populations conferred mixed results. Several warnings are included in the role of serum phosphorus on cardiovascular disease in normal populations. Homeostasis of serum phosphate is obtained by the cooperation between regulatory hormones, cellular receptors and bone metabolic factors. There is the probability that one or more phosphate regulatory factors, rather than phosphate directly, may be responsible for observed associations with calcification and cardiovascular events in normal populations. Experimental studies have shown that the restriction of dietary phosphate prevents the progression of kidney dysfunction, although high dietary phosphate aggravates the renal function. In the current review, we discuss the role of serum phosphorus on progression of renal dysfunction and cardiovascular outcomes in chronic kidney disease patients and its involvement in important health risks in the general population.
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Registered trials
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