Evidence map›Paper›PMID 34631458›Full record

ReviewWorld journal of psychiatry2021

Genetics of adult attachment: An updated review of the literature.

Leire Erkoreka, Mercedes Zumarraga, Aurora Arrue, M Isabel Zamalloa, Ainara Arnaiz, Olga Olivas, Teresa Moreno-Calle, Estela Saez, Jon Garcia, Elena Marin and 3 more

Open access · diamondAbstract readReview
In one paragraph

Review in World journal of psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Leire ErkorekaDepartment of Psychiatry, Galdakao-Usansolo Hospital, Osakidetza Basque Health Service, Galdakao 48960, Spain.
Mercedes ZumarragaGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Aurora ArrueGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
M Isabel ZamalloaGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Ainara ArnaizGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Olga OlivasGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Teresa Moreno-CalleDepartment of Psychiatry, Galdakao-Usansolo Hospital, Osakidetza Basque Health Service, Galdakao 48960, Spain.
Estela SaezDepartment of Psychiatry, Galdakao-Usansolo Hospital, Osakidetza Basque Health Service, Galdakao 48960, Spain.
Jon GarciaDepartment of Neurosciences, University of the Basque Country UPV/EHU, Leioa 48940, Spain.
Elena MarinGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Noemi VarelaGrupo Red de Salud Mental, Biocruces Bizkaia Health Research Institute, Barakaldo 48903, Spain.
Ana Gonzalez-PintoDepartment of Psychiatry, BioAraba Research Institute, Araba University Hospital, University of the Basque Country (UPV/EHU), CIBERSAM, Vitoria-Gasteiz 01004, Spain.
Nieves BasterrecheZamudio Hospital, Bizkaia Mental Health Network, Osakidetza Basque Health Service, Zamudio 48170, Spain.
BioCruces Health research Institute · ESHospital de Galdakao · ESUniversity of the Basque Country · ESOsakidetza · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Attachment style, which has been theorized to be rooted in childhood bonding experiences, influences adult cognitive, emotional and interpersonal functioning. Despite its relationship with early experiences, research indicates that the continuity of attachment style across childhood and adulthood is only partial, being a malleable tendency that is shaped throughout development, with an increasing influence of genetics, as it occurs in other cognitive and behavioral phenotypes. Genetic research indicates that up to 45% of the variability in anxious and 39% in avoidant adult attachment style could be explained by genetic causes, but the precise mechanisms remain unclear. A narrative review is conducted analyzing the existing literature regarding the implication of candidate genes related to oxytocin, dopaminergic pathways, serotonergic pathways and brain-derived neurotrophic factor in adult attachment, with both vulnerability and differential susceptibility approaches, yielding mixed results. We highlight the lack of genome-wide studies and the scarcity of epigenetic investigation. Based on the existing data, we conclude that the genetics of adult attachment is an area that requires further research to clarify its etiological role and that it should be preferably approached as an interaction between nature and nurture.

Indexed as

Adult attachmentBrain-derived neurotrophic factorDopamineGeneticsMethylationOxytocinSerotonin

Identifiers

PMID34631458
PMCPMC8474999
OpenAlexW3201426892

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.