Evidence map›Paper›PMID 34631417›Full record

ArticleBrain plasticity (Amsterdam, Netherlands)2021

Identification and Characterisation of cis-Regulatory Elements Upstream of the Human Receptor Tyrosine Kinase Gene

Alexander D Walsh, Laura J Johnson, Alexandra J Harvey, Trevor J Kilpatrick, Michele D Binder

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain plasticity (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Alexander D WalshThe Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Laura J JohnsonThe Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Alexandra J HarveySchool of BioSciences, University of Melbourne, Parkville, Melbourne, Australia.
Trevor J KilpatrickThe Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
Michele D BinderThe Florey Institute of Neuroscience and Mental Health, Parkville, Melbourne, Australia.
The University of Melbourne · AUFlorey Institute of Neuroscience and Mental Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background

objectiveWhile the cell types and tissues that express

methodsWe cloned and characterized the 5' upstream region of

resultsThis study identified identified both proximal and distal-acting DNA elements that promote transcription. The strongest promoter activity was identified in an ∼850 bp region situated 3 kb upstream of the

conclusionsElucidating the genetic mechanisms that regulate

Indexed as

gene expression regulationMERTKmultiple sclerosismyeloid cellspromoter regionstranscription

Identifiers

PMID34631417
PMCPMC8461731
OpenAlexW3028938161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.