Evidence map›Paper›PMID 34631356›Full record

Review3 Biotech2021

Calcium carbonate nano- and microparticles: synthesis methods and biological applications.

Preksha Fadia, Simona Tyagi, Stuti Bhagat, Abhishek Nair, Pooja Panchal, Harsh Dave, Sadev Dang, Sanjay Singh

Open access · greenAbstract readReview
In one paragraph

Review in 3 Biotech, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 101 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  8. Article
  9. Capturing and converting COSeparation and purification technology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Preksha FadiaDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Simona TyagiDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Stuti BhagatDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Abhishek NairDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Pooja PanchalDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Harsh DaveDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Sadev DangDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.
Sanjay SinghDivision of Biological and Life Sciences, Nanomaterials and Toxicology Laboratory, School of Arts and Sciences, Central Campus, Ahmedabad University, Navrangpura, Ahmedabad, Gujarat 380009 India.ORCID 0000-0002-6256-7091
Ahmedabad University · INNational Institute of Animal Biotechnology · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calcium carbonate micro- and nanoparticles are considered as chemically inert materials. Therefore, they are widely considered in the field of biosensing, drug delivery, and as filler material in plastic, paper, paint, sealant, and adhesive industries. The unusual properties of calcium carbonate-based nanomaterials, such as biocompatibility, high surface-to-volume ratio, robust nature, easy synthesis, and surface functionalization, and ability to exist in a variety of morphologies and polymorphs, make them an ideal candidate for both industrial and biomedical applications. Significant research efforts have been devoted for developing novel synthesis methods of calcium carbonate particles in micrometer and nanometer dimensions. This review highlights different approaches of the synthesis of calcium carbonate micro- and nanoparticles, such as precipitation, slow carbonation, emulsion, polymer-mediated method, including in-situ polymerization, mechano-chemical, microwave-assisted method, and biological methods. The applications of these versatile calcium carbonate micro- and nanoparticles in the biomedical field (such as in drug delivery, therapeutics, tissue engineering, antimicrobial activity, biosensing applications), in industries, and environmental sector has also been comprehensively covered.

Indexed as

CalciteDrug deliveryFiller materialPrecipitationVaterite

Identifiers

PMID34631356
PMCPMC8497680
OpenAlexW3201693484

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.