Evidence map›Paper›PMID 34631219›Full record

ArticleAging and disease2021

Targeting Mitochondrial Network Disorganization is Protective in

Emily Machiela, Paige D Rudich, Annika Traa, Ulrich Anglas, Sonja K Soo, Megan M Senchuk, Jeremy M Van Raamsdonk

Open access · goldAbstract read
In one paragraph

Article in Aging and disease, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
  6. Unraveling Molecular Targets for Neurodegenerative Diseases ThroughInternational journal of molecular sciences · 2025
    Review
  7. A Brief Review on Caenorhabditis elegans Role in Modelling Neurodegenerative Disease.Central nervous system agents in medicinal chemistry · 2025
    Review
  8. Studying the mechanisms of neurodegeneration:Frontiers in cellular neuroscience · 2025
    Review
  9. Article
  10. Article
  11. ULP-2 SUMO protease regulates UPRFree radical biology & medicine · 2024
    Article
  12. Review
  13. Article
  14. Review
  15. Biomolecules · 2023
    Review
  16. Article
  17. Biomolecules · 2022
    Review
  18. Review
  19. Article
  20. Frontiers in aging · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Emily Machiela1Laboratory of Aging and Neurodegenerative Disease, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids MI 49503, USA.
Paige D Rudich2Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H4A 3J1, Canada.
Annika Traa2Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H4A 3J1, Canada.
Ulrich Anglas2Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H4A 3J1, Canada.
Sonja K Soo2Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, H4A 3J1, Canada.
Megan M Senchuk1Laboratory of Aging and Neurodegenerative Disease, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids MI 49503, USA.
Jeremy M Van Raamsdonk1Laboratory of Aging and Neurodegenerative Disease, Center for Neurodegenerative Science, Van Andel Research Institute, Grand Rapids MI 49503, USA.
McGill University · CAMcGill University Health Centre · CAVan Andel Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Huntington's disease (HD) is an adult-onset neurodegenerative disease caused by a trinucleotide CAG repeat expansion in the

Indexed as

aggregationanimal modelC. elegansDRP1geneticsHuntington’s diseasemitochondriamitochondrial dynamicsneurodegenerationneuroprotection

Identifiers

PMID34631219
PMCPMC8460302
OpenAlexW3204365504

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.